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Dgkz diacylglycerol kinase zeta [ Mus musculus (house mouse) ]

Gene ID: 104418, updated on 19-Sep-2021

Summary

Official Symbol
Dgkzprovided by MGI
Official Full Name
diacylglycerol kinase zetaprovided by MGI
Primary source
MGI:MGI:1278339
See related
Ensembl:ENSMUSG00000040479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mDGK[z]; E130307B02Rik; F730209L11Rik
Expression
Broad expression in thymus adult (RPKM 128.6), cerebellum adult (RPKM 47.0) and 24 other tissues See more
Orthologs
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Genomic context

See Dgkz in Genome Data Viewer
Location:
2; 2 E1
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91763167..91806788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91932822..91976443, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91772979..91803720, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene predicted gene, 39876 Neighboring gene microRNA 6999 Neighboring gene midkine Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene predicted gene, 31473

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diacylglycerol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of postsynaptic density structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of postsynaptic density structure IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maintenance of postsynaptic density structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
diacylglycerol kinase zeta
Names
DAG kinase zeta
DGK-zeta
diglyceride kinase zeta
NP_001160069.1
NP_612179.2
XP_006498600.1
XP_006498601.1
XP_006498602.1
XP_006498603.1
XP_006498604.1
XP_006498605.1
XP_006498606.1
XP_011237543.1
XP_011237546.1
XP_017170356.1
XP_017170364.1
XP_017170367.1
XP_030102338.1
XP_036013070.1
XP_036013088.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166597.1NP_001160069.1  diacylglycerol kinase zeta isoform 1

    See identical proteins and their annotated locations for NP_001160069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK087503, BE862117, BY545365, CD564532
    Consensus CDS
    CCDS50643.1
    UniProtKB/TrEMBL
    A2AHK0
    Related
    ENSMUSP00000106934.2, ENSMUST00000111303.2
    Conserved Domains (7) summary
    smart00045
    Location:641798
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:492613
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:488811
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:9891105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9891083
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:9791015
    ANK; ANK repeat [structural motif]
    cl00040
    Location:367426
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  2. NM_138306.2NP_612179.2  diacylglycerol kinase zeta isoform 2

    See identical proteins and their annotated locations for NP_612179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK087503, AK204403, BB834774, BQ443200, BY733951
    Consensus CDS
    CCDS16441.1
    UniProtKB/Swiss-Prot
    Q80UP3
    Related
    ENSMUSP00000028667.4, ENSMUST00000028667.10
    Conserved Domains (7) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:795911
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795889
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:785821
    ANK; ANK repeat [structural motif]
    cl00040
    Location:173232
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91763167..91806788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498539.1XP_006498602.1  diacylglycerol kinase zeta isoform X4

    Conserved Domains (5) summary
    smart00045
    Location:464621
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:315436
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:854887
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:826920
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:190240
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  2. XM_006498541.3XP_006498604.1  diacylglycerol kinase zeta isoform X7

    UniProtKB/TrEMBL
    A2AHJ7
    Related
    ENSMUSP00000106937.3, ENSMUST00000099709.10
    Conserved Domains (5) summary
    smart00045
    Location:464621
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:315436
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:802838
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:812906
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:190240
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  3. XM_006498543.2XP_006498606.1  diacylglycerol kinase zeta isoform X10

    Related
    ENSMUSP00000159231.2, ENSMUST00000239257.2
    Conserved Domains (5) summary
    smart00045
    Location:452609
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:790826
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:800894
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:178228
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  4. XM_036157177.1XP_036013070.1  diacylglycerol kinase zeta isoform X6

    Conserved Domains (6) summary
    smart00045
    Location:452609
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:841874
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:813907
    Ank_2; Ankyrin repeats (3 copies)
    cd20849
    Location:93166
    C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
    cd20895
    Location:176250
    C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
  5. XM_006498540.2XP_006498603.1  diacylglycerol kinase zeta isoform X5

    Conserved Domains (5) summary
    smart00045
    Location:452609
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:842875
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:814908
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:178228
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  6. XM_030246478.2XP_030102338.1  diacylglycerol kinase zeta isoform X9

    Conserved Domains (5) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:836869
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:808902
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:173223
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  7. XM_006498542.5XP_006498605.1  diacylglycerol kinase zeta isoform X8

    Conserved Domains (5) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:837870
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:809903
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:173223
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  8. XM_036157195.1XP_036013088.1  diacylglycerol kinase zeta isoform X13

    Conserved Domains (5) summary
    smart00045
    Location:225382
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:76197
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:615648
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587681
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:123
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  9. XM_006498537.2XP_006498600.1  diacylglycerol kinase zeta isoform X1

    Conserved Domains (5) summary
    smart00045
    Location:641798
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:492613
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:10311064
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:10031097
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:367417
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  10. XM_006498538.3XP_006498601.1  diacylglycerol kinase zeta isoform X2

    Conserved Domains (5) summary
    smart00045
    Location:641798
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:492613
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:10301063
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:10021096
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:367417
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  11. XM_017314867.2XP_017170356.1  diacylglycerol kinase zeta isoform X3

    Conserved Domains (5) summary
    smart00045
    Location:641798
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:492613
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:9801016
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:9901084
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:367417
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  12. XM_017314878.1XP_017170367.1  diacylglycerol kinase zeta isoform X11

    Conserved Domains (5) summary
    smart00045
    Location:327484
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:178299
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:717750
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:689783
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:53103
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  13. XM_017314875.2XP_017170364.1  diacylglycerol kinase zeta isoform X11

    Conserved Domains (5) summary
    smart00045
    Location:327484
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:178299
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:717750
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:689783
    Ank_2; Ankyrin repeats (3 copies)
    cl00040
    Location:53103
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  14. XM_011239241.4XP_011237543.1  diacylglycerol kinase zeta isoform X12

    Conserved Domains (3) summary
    smart00046
    Location:492613
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:367417
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02440
    Location:641727
    DAGK_acc; Diacylglycerol kinase accessory domain
  15. XM_011239244.2XP_011237546.1  diacylglycerol kinase zeta isoform X14

    Conserved Domains (2) summary
    smart00046
    Location:492594
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:367417
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RNA

  1. XR_003949943.2 RNA Sequence

  2. XR_374381.3 RNA Sequence

  3. XR_004937408.1 RNA Sequence

  4. XR_003949868.2 RNA Sequence

  5. XR_004937410.1 RNA Sequence

  6. XR_004937411.1 RNA Sequence

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