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Rars arginyl-tRNA synthetase [ Mus musculus (house mouse) ]

Gene ID: 104458, updated on 5-Jan-2022

Summary

Official Symbol
Rarsprovided by MGI
Official Full Name
arginyl-tRNA synthetaseprovided by MGI
Primary source
MGI:MGI:1914297
See related
Ensembl:ENSMUSG00000018848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rars1; AL033339; AW985894; 2610011N19Rik; 2610037E21Rik
Summary
Enables arginine-tRNA ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in placenta adult (RPKM 41.2), CNS E11.5 (RPKM 34.3) and 26 other tissues See more
Orthologs
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Genomic context

See Rars in Genome Data Viewer
Location:
11; 11 A4
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35699207..35725355, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (35808381..35834528, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (35621883..35648030, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 103-1 Neighboring gene pantothenate kinase 3 Neighboring gene fibrillarin-like 1 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene teneurin transmembrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables arginine binding ISO
Inferred from Sequence Orthology
more info
 
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arginine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arginine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arginyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arginine--tRNA ligase, cytoplasmic
Names
argRS
arginyl-tRNA synthetase, cytoplasmic
NP_080212.2
XP_036012095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025936.3NP_080212.2  arginine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_080212.2

    Status: VALIDATED

    Source sequence(s)
    AK076160, CB523934, CF748175
    Consensus CDS
    CCDS24544.1
    UniProtKB/Swiss-Prot
    Q9D0I9
    Related
    ENSMUSP00000018992.4, ENSMUST00000018992.4
    Conserved Domains (4) summary
    cd00671
    Location:193457
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:79166
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:80660
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:498660
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    35699207..35725355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156202.1XP_036012095.1  arginine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    PLN02286
    Location:8588
    PLN02286; arginine-tRNA ligase
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