U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SNHG14 small nucleolar RNA host gene 14 [ Homo sapiens (human) ]

Gene ID: 104472715, updated on 12-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SNHG14provided by HGNC
Official Full Name
small nucleolar RNA host gene 14provided by HGNC
Primary source
HGNC:HGNC:37462
See related
MIM:616259; AllianceGenome:HGNC:37462
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
115HG; LNCAT; UBE3A-AS; UBE3AATS; UBE3A-AS1; UBE3A-ATS; NCRNA00214; U-UBE3A-ATS; IC-SNURF-SNRPN
Summary
This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SNHG14 in Genome Data Viewer
Location:
15q11.2
Exon count:
148
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24823608..25419462)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (22560260..23156060)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (25068755..25664609)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr15:24877390-24877896 Neighboring gene Prader-Willi region non-protein coding RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:24932126-24932730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24941505-24942052 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24942053-24942599 Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:25017418-25018314 and GRCh37_chr15:25018315-25019210 Neighboring gene nuclear pore associated protein 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25101506-25102019 Neighboring gene Sharpr-MPRA regulatory region 849 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25103559-25104072 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25104073-25104585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25107499-25108228 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25143773-25144405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25145037-25145537 Neighboring gene small nuclear ribonucleoprotein polypeptide N Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25196020-25196660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:25200549-25201114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25201115-25201680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25201681-25202246 Neighboring gene ribosomal protein S27 pseudogene 2 Neighboring gene ribosomal protein L5 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 7323 Neighboring gene small nucleolar RNA, C/D box 107 Neighboring gene small nucleolar RNA, C/D box 108 Neighboring gene SNRPN upstream open reading frame Neighboring gene small nucleolar RNA, C/D box 64 Neighboring gene uncharacterized LOC128966705 Neighboring gene Prader Willi/Angelman region RNA, SNRPN neighbor Neighboring gene small nucleolar RNA, C/D box 116-1 Neighboring gene small nucleolar RNA, C/D box 116-2 Neighboring gene small nucleolar RNA, C/D box 109A Neighboring gene small nucleolar RNA, C/D box 116-3 Neighboring gene small nucleolar RNA, C/D box 116-4 Neighboring gene Prader Willi/Angelman region RNA 5 Neighboring gene small nucleolar RNA, C/D box 116-10 Neighboring gene small nucleolar RNA, C/D box 116-5 Neighboring gene small nucleolar RNA, C/D box 116-11 Neighboring gene small nucleolar RNA, C/D box 116-12 Neighboring gene small nucleolar RNA, C/D box 116-6 Neighboring gene small nucleolar RNA, C/D box 116-15 Neighboring gene small nucleolar RNA, C/D box 116-14 Neighboring gene small nucleolar RNA, C/D box 116-13 Neighboring gene small nucleolar RNA, C/D box 116-17 Neighboring gene small nucleolar RNA, C/D box 116-16 Neighboring gene small nucleolar RNA, C/D box 116-7 Neighboring gene small nucleolar RNA, C/D box 116-18 Neighboring gene small nucleolar RNA, C/D box 116-20 Neighboring gene small nucleolar RNA, C/D box 116-19 Neighboring gene small nucleolar RNA, C/D box 116-8 Neighboring gene small nucleolar RNA, C/D box 116-9 Neighboring gene small nucleolar RNA, C/D box 116-21 Neighboring gene small nucleolar RNA, C/D box 116-22 Neighboring gene small nucleolar RNA, C/D box 116-23 Neighboring gene small nucleolar RNA, C/D box 116-24 Neighboring gene small nucleolar RNA, C/D box 116-25 Neighboring gene small nucleolar RNA, C/D box 116-26 Neighboring gene small nucleolar RNA, C/D box 116-27 Neighboring gene small nucleolar RNA, C/D box 116-28 Neighboring gene small nucleolar RNA, C/D box 116-29 Neighboring gene small nucleolar RNA, C/D box 116-30 Neighboring gene Prader Willi/Angelman region RNA 6 Neighboring gene uncharacterized LOC124903592 Neighboring gene small nucleolar RNA, C/D box 115-1 Neighboring gene small nucleolar RNA, C/D box 115-2 Neighboring gene small nucleolar RNA, C/D box 115-3 Neighboring gene small nucleolar RNA, C/D box 115-11 Neighboring gene small nucleolar RNA, C/D box 115-10 Neighboring gene small nucleolar RNA, C/D box 115-13 Neighboring gene small nucleolar RNA, C/D box 115-4 Neighboring gene small nucleolar RNA, C/D box 115-12 Neighboring gene small nucleolar RNA, C/D box 115-6 Neighboring gene small nucleolar RNA, C/D box 115-14 Neighboring gene small nucleolar RNA, C/D box 115-5 Neighboring gene small nucleolar RNA, C/D box 115-8 Neighboring gene small nucleolar RNA, C/D box 115-15 Neighboring gene small nucleolar RNA, C/D box 115-7 Neighboring gene small nucleolar RNA, C/D box 115-16 Neighboring gene small nucleolar RNA, C/D box 115-17 Neighboring gene small nucleolar RNA, C/D box 115-9 Neighboring gene small nucleolar RNA, C/D box 115-18 Neighboring gene small nucleolar RNA, C/D box 115-19 Neighboring gene small nucleolar RNA, C/D box 115-20 Neighboring gene small nucleolar RNA, C/D box 115-21 Neighboring gene small nucleolar RNA, C/D box 115-22 Neighboring gene small nucleolar RNA, C/D box 115-23 Neighboring gene small nucleolar RNA, C/D box 115-24 Neighboring gene small nucleolar RNA, C/D box 115-25 Neighboring gene small nucleolar RNA, C/D box 115-26 Neighboring gene small nucleolar RNA, C/D box 115-27 Neighboring gene small nucleolar RNA, C/D box 115-29 Neighboring gene small nucleolar RNA, C/D box 115-28 Neighboring gene small nucleolar RNA, C/D box 115-30 Neighboring gene Prader Willi/Angelman region RNA 1 Neighboring gene small nucleolar RNA, C/D box 115-31 Neighboring gene DMAC1 pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 115-32 Neighboring gene small nucleolar RNA, C/D box 115-34 Neighboring gene small nucleolar RNA, C/D box 115-33 Neighboring gene small nucleolar RNA, C/D box 115-35 Neighboring gene small nucleolar RNA, C/D box 115-37 Neighboring gene imprinted in Prader-Willi syndrome Neighboring gene small nucleolar RNA, C/D box 115-36 Neighboring gene small nucleolar RNA, C/D box 115-38 Neighboring gene small nucleolar RNA, C/D box 115-39 Neighboring gene small nucleolar RNA, C/D box 115-40 Neighboring gene small nucleolar RNA, C/D box 115-41 Neighboring gene small nucleolar RNA, C/D box 115-42 Neighboring gene small nucleolar RNA, C/D box 115-43 Neighboring gene small nucleolar RNA, C/D box 115-44 Neighboring gene small nucleolar RNA, C/D box 115-45 Neighboring gene small nucleolar RNA, C/D box 115-46 Neighboring gene small nucleolar RNA, C/D box 115-47 Neighboring gene small nucleolar RNA, C/D box 115-48 Neighboring gene Prader Willi/Angelman region RNA 4 Neighboring gene small nucleolar RNA, C/D box 109B Neighboring gene Sharpr-MPRA regulatory region 5757 Neighboring gene ubiquitin protein ligase E3A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:25683287-25684232 and GRCh37_chr15:25684233-25685178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:25726194-25726733 Neighboring gene Sharpr-MPRA regulatory region 718 Neighboring gene long intergenic non-protein coding RNA 2250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:25789643-25790842 Neighboring gene uncharacterized LOC107984789 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:25808594-25809158 Neighboring gene uncharacterized LOC124903448

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling. Shen M, et al. Cell Mol Biol (Noisy-le-grand), 2023 Mar 31. PMID 37300688
  2. LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells. Li L, et al. Cancer Gene Ther, 2023 May. PMID 36599973
  3. Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis. Yuan X, et al. Metab Brain Dis, 2022 Oct. PMID 35781593
  4. Mechanism of Autonomic Exercise Improving Cognitive Function of Alzheimer's Disease by Regulating lncRNA SNHG14. He Y, et al. Am J Alzheimers Dis Other Demen, 2021 Jan-Dec. PMID 34338033, Free PMC Article
  5. Long non-coding RNA SNHG14 aggravates LPS-induced acute kidney injury through regulating miR-495-3p/HIPK1. Yang N, et al. Acta Biochim Biophys Sin (Shanghai), 2021 May 21. PMID 33856026

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Breast cancer-derived exosomal lncRNA SNHG14 induces normal fibroblast activation to cancer-associated fibroblasts via the EBF1/FAM171A1 axis.
    Title: Breast cancer-derived exosomal lncRNA SNHG14 induces normal fibroblast activation to cancer-associated fibroblasts via the EBF1/FAM171A1 axis.
  2. Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137.
    Title: Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137.
  3. SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling.
    Title: SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling.
  4. LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
    Title: LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
  5. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
    Title: Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
  6. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
    Title: Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
  7. Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis.
    Title: Long noncoding RNA SNHG14 knockdown exerts a neuroprotective role in MPP(+)-induced Parkinson's disease cell model through mediating miR-135b-5p/KPNA4 axis.
  8. LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation.
    Title: LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation.
  9. LncRNA SNHG14 Sponges miR-206 to Affect Proliferation, Apoptosis, and Metastasis of Hepatocellular Carcinoma Cells by Regulating SOX9.
    Title: LncRNA SNHG14 Sponges miR-206 to Affect Proliferation, Apoptosis, and Metastasis of Hepatocellular Carcinoma Cells by Regulating SOX9.
  10. lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p.
    Title: lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

Go to the top of the page Help

Homology

Other Names

  • UBE3A antisense RNA 1 (non-protein coding)
  • UBE3A antisense transcript
  • large noncoding antisense transcript
  • small nucleolar RNA host gene 14 (non-protein coding)

Clone Names

  • DKFZp762N022, DKFZp686C0927, DKFZp686M12165

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_146177.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090983, AC124303, AC124312, AC124997, AF319524, AF400485, AF400486, AF400487, AF400490, AF400491, AF400492, AF400497, AF400498, AF400499, AF400501, AF400502, AY362864, AY362865, AY421730, BC080646, CN389953, DA296172, DN990150

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    24823608..25419462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    22560260..23156060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials