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Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 104709, updated on 16-Oct-2021

Summary

Official Symbol
Pik3r6provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 5provided by MGI
Primary source
MGI:MGI:2144613
See related
Ensembl:ENSMUSG00000046207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p84; BB220380; p87PIKAP; p84 PIKAP; p87(PIKAP)
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in lung adult (RPKM 5.1), mammary gland adult (RPKM 3.9) and 27 other tissues See more
Orthologs
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Genomic context

See Pik3r6 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68393845..68443524)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68503019..68552698)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68316521..68366200)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32046 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene major facilitator superfamily domain containing 6-like Neighboring gene predicted gene, 40036

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 6
Names
p84 PI3K adapter protein
p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
phosphoinositide 3-kinase gamma adapter protein of 87 kDa
phosphoinositide-3-kinase, regulatory subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004435.3NP_001004435.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 2

    See identical proteins and their annotated locations for NP_001004435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK153039, AY753194, BX629873, BY202586
    Consensus CDS
    CCDS24866.1
    UniProtKB/Swiss-Prot
    Q3U6Q4
    Related
    ENSMUSP00000099673.2, ENSMUST00000102613.8
    Conserved Domains (1) summary
    pfam10486
    Location:34749
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. NM_001081566.2NP_001075035.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001075035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform 1.
    Source sequence(s)
    AK153039, BX629873, BY202586
    Consensus CDS
    CCDS36186.1
    UniProtKB/Swiss-Prot
    Q3U6Q4
    Related
    ENSMUSP00000052522.7, ENSMUST00000060441.7
    Conserved Domains (1) summary
    pfam10486
    Location:34753
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. NR_126153.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK036623, AK151178, BX629873, BY202586
    Related
    ENSMUST00000153671.8
  2. NR_126154.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in two internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK036623, AK151178, AK153039, AL606831, BX629873, BY202586

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68393845..68443524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314217.2XP_017169706.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

    Conserved Domains (1) summary
    pfam10486
    Location:32546
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. XM_006531950.1XP_006532013.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    Conserved Domains (1) summary
    pfam10486
    Location:32499
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  3. XM_006531948.1XP_006532011.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

    Conserved Domains (1) summary
    pfam10486
    Location:38716
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  4. XM_030245460.1XP_030101320.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

    Conserved Domains (1) summary
    pfam10486
    Location:35394
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. XR_001779856.2 RNA Sequence

  2. XR_003949212.1 RNA Sequence

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