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Aspg asparaginase [ Mus musculus (house mouse) ]

Gene ID: 104816, updated on 5-Mar-2024

Summary

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Official Symbol
Aspgprovided by MGI
Official Full Name
asparaginaseprovided by MGI
Primary source
MGI:MGI:2144822
See related
Ensembl:ENSMUSG00000037686 AllianceGenome:MGI:2144822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm690; A530050D06Rik
Summary
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to act upstream of or within lipid catabolic process. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 84.5), colon adult (RPKM 14.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.14 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112073117..112094007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112106683..112127573)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tudor domain containing 9 Neighboring gene retinal degeneration 3-like Neighboring gene predicted gene, 46381 Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene microRNA 203b Neighboring gene microRNA 203 Neighboring gene kinesin family member 26A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups ISO
Inferred from Sequence Orthology
more info
  
enables asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparaginase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in asparagine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
60 kDa lysophospholipase
Names
60 kDa lysophospholipase [Includes: L-asparaginase
asparaginase homolog
lysophospholipase-transacylase
NP_001074638.1
XP_006515408.1
XP_006515409.1
XP_006515410.1
XP_006515411.1
XP_006515412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081169.1 → NP_001074638.1  60 kDa lysophospholipase

    See identical proteins and their annotated locations for NP_001074638.1

    Status: PROVISIONAL

    Source sequence(s)
    AC112520
    Consensus CDS
    CCDS36567.1
    UniProtKB/Swiss-Prot
    A0JNU3
    Related
    ENSMUSP00000078369.5, ENSMUST00000079400.6
    Conserved Domains (3) summary
    PLN03192
    Location:373 → 550
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    cl00216
    Location:9 → 361
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112073117..112094007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515345.5 → XP_006515408.1  60 kDa lysophospholipase isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:330 → 507
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:387 → 418
    ANK; ANK repeat [structural motif]
    cl00216
    Location:31 → 318
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

  2. XM_006515346.1 → XP_006515409.1  60 kDa lysophospholipase isoform X2

    See identical proteins and their annotated locations for XP_006515409.1

    Conserved Domains (3) summary
    PLN03192
    Location:255 → 432
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:312 → 343
    ANK; ANK repeat [structural motif]
    cl00216
    Location:1 → 243
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

  3. XM_006515349.1 → XP_006515412.1  60 kDa lysophospholipase isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:211 → 388
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:268 → 299
    ANK; ANK repeat [structural motif]
    cl00216
    Location:2 → 199
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

  4. XM_006515348.1 → XP_006515411.1  60 kDa lysophospholipase isoform X2

    See identical proteins and their annotated locations for XP_006515411.1

    Conserved Domains (3) summary
    PLN03192
    Location:255 → 432
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:312 → 343
    ANK; ANK repeat [structural motif]
    cl00216
    Location:1 → 243
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

  5. XM_006515347.5 → XP_006515410.1  60 kDa lysophospholipase isoform X2

    See identical proteins and their annotated locations for XP_006515410.1

    Conserved Domains (3) summary
    PLN03192
    Location:255 → 432
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:312 → 343
    ANK; ANK repeat [structural motif]
    cl00216
    Location:1 → 243
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JNU3.1 GenPept UniProtKB/Swiss-Prot:A0JNU3

Gene LinkOut

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