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Rdh14 retinol dehydrogenase 14 (all-trans and 9-cis) [ Mus musculus (house mouse) ]

Gene ID: 105014, updated on 11-Apr-2024

Summary

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Official Symbol
Rdh14provided by MGI
Official Full Name
retinol dehydrogenase 14 (all-trans and 9-cis)provided by MGI
Primary source
MGI:MGI:1920402
See related
Ensembl:ENSMUSG00000020621 AllianceGenome:MGI:1920402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAN2; 3110030G19Rik
Summary
Enables NADP-retinol dehydrogenase activity. Acts upstream of or within retinol metabolic process. Located in mitochondrion. Orthologous to human RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 13.1), adrenal adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 5.29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (10440752..10445562)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (10390748..10395562)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5319 Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene predicted gene, 38407 Neighboring gene STARR-seq mESC enhancer starr_31530 Neighboring gene STARR-seq mESC enhancer starr_31531 Neighboring gene STARR-seq mESC enhancer starr_31532 Neighboring gene predicted gene 4928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RDH13L, an enzyme responsible for the aldehyde-alcohol redox coupling reaction (AL-OL coupling reaction) to supply 11-cis retinal in the carp cone retinoid cycle. Sato S, et al. J Biol Chem, 2015 Jan 30. PMID 25533474, Free PMC Article
  2. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. Haeseleer F, et al. J Biol Chem, 2002 Nov 22. PMID 12226107, Free PMC Article
  3. Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. Lee J, et al. Mol Cell Proteomics, 2007 Apr. PMID 17208939, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 14
Names
alcohol dehydrogenase PAN2
alcohol dehydrogenase PAN2; expressed sequence AW215439
NP_076186.1
XP_006515006.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023697.2 → NP_076186.1  retinol dehydrogenase 14

    See identical proteins and their annotated locations for NP_076186.1

    Status: VALIDATED

    Source sequence(s)
    AF303831, BB200972, BE686521
    Consensus CDS
    CCDS25811.1
    UniProtKB/Swiss-Prot
    Q9ERI6
    UniProtKB/TrEMBL
    Q569U9
    Related
    ENSMUSP00000020947.6, ENSMUST00000020947.7
    Conserved Domains (2) summary
    PRK06197
    Location:43 → 332
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:44 → 326
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    10440752..10445562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514943.5 → XP_006515006.1  retinol dehydrogenase 14 isoform X1

    UniProtKB/TrEMBL
    Q569U9
    Conserved Domains (1) summary
    cl21454
    Location:3 → 285
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERI6.1 GenPept UniProtKB/Swiss-Prot:Q9ERI6

Gene LinkOut

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