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Slc17a3 solute carrier family 17 (sodium phosphate), member 3 [ Mus musculus (house mouse) ]

Gene ID: 105355, updated on 5-Mar-2024

Summary

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Official Symbol
Slc17a3provided by MGI
Official Full Name
solute carrier family 17 (sodium phosphate), member 3provided by MGI
Primary source
MGI:MGI:2389216
See related
Ensembl:ENSMUSG00000036083 AllianceGenome:MGI:2389216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npt4
Summary
Predicted to enable several functions, including anion transmembrane transporter activity; toxin transmembrane transporter activity; and urate transmembrane transporter activity. Predicted to be involved in organic anion transport; urate metabolic process; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Predicted to be active in lysosome. Predicted to be integral component of plasma membrane. Is expressed in several structures, including liver and urinary system. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 17.4), liver adult (RPKM 4.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 9.95 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24020905..24044701)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23836922..23860718)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11337 Neighboring gene solute carrier family 17 (sodium phosphate), member 2 Neighboring gene solute carrier family 17 (sodium phosphate), member 1 Neighboring gene solute carrier family 17 (sodium phosphate), member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. Cheret C, et al. J Mol Biol, 2002 Oct 4. PMID 12367519
  2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables toxin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164743.1 → NP_001158215.1  sodium-dependent phosphate transport protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001158215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA986956, AK143896, AL590388
    Consensus CDS
    CCDS49220.1
    UniProtKB/TrEMBL
    Q5SZ92, Q8VCY5
    Related
    ENSMUSP00000106052.3, ENSMUST00000110422.3
    Conserved Domains (1) summary
    cd17318
    Location:6 → 446
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. NM_134069.3 → NP_598830.2  sodium-dependent phosphate transport protein 4 isoform 1

    See identical proteins and their annotated locations for NP_598830.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA986956, AK143896, AL590388
    Consensus CDS
    CCDS26371.1
    UniProtKB/TrEMBL
    G3UWD9, G5E894, Q8VCY5
    Related
    ENSMUSP00000039062.8, ENSMUST00000039721.14
    Conserved Domains (1) summary
    cd17318
    Location:42 → 482
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24020905..24044701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516521.4 → XP_006516584.1  sodium-dependent phosphate transport protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006516584.1

    UniProtKB/TrEMBL
    Q5SZ92, Q8VCY5
    Conserved Domains (1) summary
    cd17318
    Location:6 → 446
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. XM_006516520.4 → XP_006516583.1  sodium-dependent phosphate transport protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006516583.1

    UniProtKB/TrEMBL
    G3UWD9, G5E894, Q8VCY5
    Conserved Domains (1) summary
    cd17318
    Location:42 → 482
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  3. XM_017315349.1 → XP_017170838.1  sodium-dependent phosphate transport protein 4 isoform X1

    UniProtKB/TrEMBL
    G3UWD9, G5E894, Q8VCY5
    Conserved Domains (1) summary
    cd17318
    Location:42 → 482
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  4. XM_006516522.2 → XP_006516585.1  sodium-dependent phosphate transport protein 4 isoform X3

    Conserved Domains (1) summary
    TIGR00894
    Location:3 → 288
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RNA

  1. XR_873126.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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