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PCSK9 proprotein convertase subtilisin/kexin type 9 [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105495119, updated on 13-Mar-2024

Summary

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Gene symbol
PCSK9
Gene description
proprotein convertase subtilisin/kexin type 9
See related
Ensembl:ENSMNEG00000036087
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
PC9
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012011688.1 (35409416..35437703)

NW_012011688.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 61 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene ubiquitin specific peptidase 24 Neighboring gene glycogenin-1 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012011688 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species. Ding K, et al. PLoS One, 2007 Oct 31. PMID 17971861, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 9
Names
Proprotein convertase 9
Subtilisin/kexin-like protease PC9
convertase subtilisin/kexin type 9 preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012011688.1 Reference Mnem_1.0

    Range
    35409416..35437703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011764351.2 → XP_011762653.1  proprotein convertase subtilisin/kexin type 9 isoform X2

    UniProtKB/Swiss-Prot
    A8T662
    Conserved Domains (3) summary
    cd04077
    Location:275 → 539
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam00082
    Location:298 → 540
    Peptidase_S8; Subtilase family
    pfam05922
    Location:196 → 268
    Inhibitor_I9; Peptidase inhibitor I9

  2. XM_011764348.2 → XP_011762650.1  proprotein convertase subtilisin/kexin type 9 isoform X1

    See identical proteins and their annotated locations for XP_011762650.1

    UniProtKB/Swiss-Prot
    A8T662
    UniProtKB/TrEMBL
    A0A2K6CND1
    Related
    ENSMNEP00000025186.1, ENSMNET00000049461.1
    Conserved Domains (3) summary
    cd04077
    Location:275 → 540
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam00082
    Location:299 → 541
    Peptidase_S8; Subtilase family
    pfam05922
    Location:196 → 268
    Inhibitor_I9; Peptidase inhibitor I9

  3. XM_011764349.2 → XP_011762651.1  proprotein convertase subtilisin/kexin type 9 isoform X1

    See identical proteins and their annotated locations for XP_011762651.1

    UniProtKB/Swiss-Prot
    A8T662
    UniProtKB/TrEMBL
    A0A2K6CND1
    Conserved Domains (3) summary
    cd04077
    Location:275 → 540
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam00082
    Location:299 → 541
    Peptidase_S8; Subtilase family
    pfam05922
    Location:196 → 268
    Inhibitor_I9; Peptidase inhibitor I9

  4. XM_011764350.2 → XP_011762652.1  proprotein convertase subtilisin/kexin type 9 isoform X1

    See identical proteins and their annotated locations for XP_011762652.1

    UniProtKB/Swiss-Prot
    A8T662
    UniProtKB/TrEMBL
    A0A2K6CND1
    Conserved Domains (3) summary
    cd04077
    Location:275 → 540
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam00082
    Location:299 → 541
    Peptidase_S8; Subtilase family
    pfam05922
    Location:196 → 268
    Inhibitor_I9; Peptidase inhibitor I9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8T662.1 GenPept UniProtKB/Swiss-Prot:A8T662

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