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LCK LCK proto-oncogene, Src family tyrosine kinase [ Aotus nancymaae (Ma's night monkey) ]

Gene ID: 105709116, updated on 15-Apr-2024

Summary

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Gene symbol
LCK
Gene description
LCK proto-oncogene, Src family tyrosine kinase
See related
Ensembl:ENSANAG00000034805
Gene type
protein coding
RefSeq status
MODEL
Organism
Aotus nancymaae
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae; Aotus
Also known as
p56-LCK
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_04 current 86718_ANA_hifiasm-v0.15.2.pri (GCF_030222135.1) Unplaced Scaffold NW_026988467.1 (28773948..28809723)
101 previous assembly Anan_2.0 (GCF_000952055.2) Unplaced Scaffold NW_018505709.1 (6475944..6515608, complement)

NW_026988467.1Genomic Context describing neighboring genes Neighboring gene myotubularin-related protein 9-like Neighboring gene eukaryotic translation initiation factor 3 subunit I Neighboring gene family with sequence similarity 167 member B Neighboring gene histone deacetylase 1 Neighboring gene beta-enolase-like Neighboring gene MARCKS like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Lck
Names
Lymphocyte cell-specific protein-tyrosine kinase
Proto-oncogene Lck
Tyrosine-protein kinase Lck
lymphocyte-specific protein tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030222135.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

Genomic

  1. NW_026988467.1 Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

    Range
    28773948..28809723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012440954.2 → XP_012296377.1  tyrosine-protein kinase Lck isoform X2

    See identical proteins and their annotated locations for XP_012296377.1

    UniProtKB/Swiss-Prot
    Q5PXS1
    UniProtKB/TrEMBL
    A0A2K5EN11
    Related
    ENSANAP00000034541.1
    Conserved Domains (4) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:245 → 494
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_012440936.2 → XP_012296359.2  tyrosine-protein kinase Lck isoform X1

  3. XM_064363627.1 → XP_064219697.1  tyrosine-protein kinase Lck isoform X1

  4. XM_012440960.2 → XP_012296383.1  tyrosine-protein kinase Lck isoform X2

    See identical proteins and their annotated locations for XP_012296383.1

    UniProtKB/Swiss-Prot
    Q5PXS1
    UniProtKB/TrEMBL
    A0A2K5EN11
    Related
    ENSANAP00000034557.1
    Conserved Domains (4) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:245 → 494
    Pkinase_Tyr; Protein tyrosine kinase

  5. XM_012440945.2 → XP_012296368.2  tyrosine-protein kinase Lck isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PXS1.4 GenPept UniProtKB/Swiss-Prot:Q5PXS1

Gene LinkOut

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