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SMC2 structural maintenance of chromosomes 2 [ Homo sapiens (human) ]

Gene ID: 10592, updated on 7-Apr-2024

Summary

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Official Symbol
SMC2provided by HGNC
Official Full Name
structural maintenance of chromosomes 2provided by HGNC
Primary source
HGNC:HGNC:14011
See related
Ensembl:ENSG00000136824 MIM:605576; AllianceGenome:HGNC:14011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPE; CAP-E; SMC-2; SMC2L1
Summary
Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 6.5), testis (RPKM 6.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q31.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (104088263..104141419)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (116267420..116315130)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (106856590..106903700)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376192 Neighboring gene uncharacterized LOC105376193 Neighboring gene long intergenic non-protein coding RNA 3094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:106855873-106856542 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:106856543-106857210 Neighboring gene SMC2 divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:106994559-106995758 Neighboring gene uncharacterized LOC105376194 Neighboring gene topoisomerase I binding, arginine and serine rich like, pseudogene Neighboring gene WDR45-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo. Han YH, et al. Neoplasma, 2020 Mar. PMID 31986889
  2. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Murakami-Tonami Y, et al. Cell Cycle, 2014. PMID 24553121, Free PMC Article
  3. Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex. Kim JH, et al. BMC Biochem, 2010 Dec 31. PMID 21194474, Free PMC Article
  4. Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils. Kawahara K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823528, Free PMC Article
  5. Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer. Feng Y, et al. Carcinogenesis, 2019 Jun 10. PMID 30794721, Free PMC Article

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo.
    Title: Structural maintenance of chromosomes 2 is identified as an oncogene in bladder cancer in vitro and in vivo.
  2. Rs3818626 and rs9895829 were significantly associated with SMC2 and TP53 messenger RNA expression.
    Title: Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.
  3. SMC2 (or the condensin complex) is a novel molecular target for the treatment of MYCN-amplified neuroblastoma.
    Title: Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.
  4. analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition
    Title: Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.
  5. SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers
    Title: Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability.
  6. WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery.
    Title: Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.
  7. Studies indicate that tagged SMC2 subunit of the condensin complex with the streptavidin-Binding Peptide optimising efficacious use of this tag for protein analysis.
    Title: Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex.
  8. human SMC2 hinge domain with short coiled coils was cloned, expressed, purified and crystallized in the orthorhombic space group C222 in native and SeMet-derivatized forms
    Title: Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils.
  9. mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL
    Title: Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
EBI GWAS Catalog
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with SMC2 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in kinetochore organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chromosome condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chromosome condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
structural maintenance of chromosomes protein 2
Names
SMC protein 2
SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
XCAP-E homolog
chromosome-associated protein E
structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042550.2 → NP_001036015.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001036015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK001485, AK124957, AL354938, AL833191, BC032705, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Related
    ENSP00000363919.3, ENST00000374787.7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001042551.2 → NP_001036016.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001036016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL354938, AL833191, BC032705, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001265602.2 → NP_001252531.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001252531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK292599, AL833191, BC144163, BF969462, BN000163
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Related
    ENSP00000286398.7, ENST00000286398.11
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_006444.3 → NP_006435.2  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_006435.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AF092563, AK124957, AL354938, AL833191, BC017845, BC032705, BC055081, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Related
    ENSP00000363925.3, ENST00000374793.8
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    104088263..104141419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518149.4 → XP_011516451.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516451.1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_047422644.1 → XP_047278600.1  structural maintenance of chromosomes protein 2 isoform X2

  3. XM_017014210.3 → XP_016869699.1  structural maintenance of chromosomes protein 2 isoform X2

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_017014211.3 → XP_016869700.1  structural maintenance of chromosomes protein 2 isoform X2

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_011518150.3 → XP_011516452.1  structural maintenance of chromosomes protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011516452.1

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_006716933.4 → XP_006716996.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006716996.1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. XM_011518151.3 → XP_011516453.1  structural maintenance of chromosomes protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011516453.1

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  8. XM_047422648.1 → XP_047278604.1  structural maintenance of chromosomes protein 2 isoform X3

  9. XM_047422649.1 → XP_047278605.1  structural maintenance of chromosomes protein 2 isoform X5

  10. XM_011518153.2 → XP_011516455.1  structural maintenance of chromosomes protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011516455.1

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (7) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1090
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1090
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. XM_024447383.2 → XP_024303151.1  structural maintenance of chromosomes protein 2 isoform X6

    UniProtKB/TrEMBL
    Q2KQ72
    Conserved Domains (1) summary
    COG1196
    Location:1 → 713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_017014206.2 → XP_016869695.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  13. XM_047422647.1 → XP_047278603.1  structural maintenance of chromosomes protein 2 isoform X2

  14. XM_017014209.2 → XP_016869698.1  structural maintenance of chromosomes protein 2 isoform X2

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  15. XM_017014208.2 → XP_016869697.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  16. XM_047422646.1 → XP_047278602.1  structural maintenance of chromosomes protein 2 isoform X2

  17. XM_011518148.3 → XP_011516450.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516450.1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2
    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (8) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193 → 287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636 → 777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1074 → 1168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  18. XM_017014212.2 → XP_016869701.1  structural maintenance of chromosomes protein 2 isoform X2

    UniProtKB/TrEMBL
    B7ZLZ7
    Conserved Domains (6) summary
    pfam06673
    Location:202 → 415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472 → 589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690 → 791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586 → 727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:1024 → 1118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    116267420..116315130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361769.1 → XP_054217744.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  2. XM_054361776.1 → XP_054217751.1  structural maintenance of chromosomes protein 2 isoform X2

  3. XM_054361767.1 → XP_054217742.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  4. XM_054361774.1 → XP_054217749.1  structural maintenance of chromosomes protein 2 isoform X2

  5. XM_054361770.1 → XP_054217745.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  6. XM_054361775.1 → XP_054217750.1  structural maintenance of chromosomes protein 2 isoform X2

  7. XM_054361780.1 → XP_054217755.1  structural maintenance of chromosomes protein 2 isoform X2

  8. XM_054361773.1 → XP_054217748.1  structural maintenance of chromosomes protein 2 isoform X2

  9. XM_054361782.1 → XP_054217757.1  structural maintenance of chromosomes protein 2 isoform X3

  10. XM_054361784.1 → XP_054217759.1  structural maintenance of chromosomes protein 2 isoform X5

  11. XM_054361783.1 → XP_054217758.1  structural maintenance of chromosomes protein 2 isoform X4

  12. XM_054361785.1 → XP_054217760.1  structural maintenance of chromosomes protein 2 isoform X6

  13. XM_054361772.1 → XP_054217747.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  14. XM_054361771.1 → XP_054217746.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  15. XM_054361779.1 → XP_054217754.1  structural maintenance of chromosomes protein 2 isoform X2

  16. XM_054361777.1 → XP_054217752.1  structural maintenance of chromosomes protein 2 isoform X2

  17. XM_054361768.1 → XP_054217743.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347, Q6IEE0, Q9P1P2

  18. XM_054361781.1 → XP_054217756.1  structural maintenance of chromosomes protein 2 isoform X2

  19. XM_054361778.1 → XP_054217753.1  structural maintenance of chromosomes protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95347.2 GenPept UniProtKB/Swiss-Prot:O95347

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