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Gm45927 predicted gene, 45927 [ Mus musculus (house mouse) ]

Gene ID: 105943584, updated on 11-Apr-2024

Summary

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Official Symbol
Gm45927provided by MGI
Official Full Name
predicted gene, 45927provided by MGI
Primary source
MGI:MGI:5825564
See related
AllianceGenome:MGI:5825564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TU52; Clk2-scamp3
Summary
This locus represents naturally occurring readthrough transcription between the neighboring Clk2 (CDC-like kinase 2) and Scamp3 (secretory carrier membrane protein 3) genes on chromosome 3. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2015]
Expression
Ubiquitous expression in adrenal adult (RPKM 58.5), ovary adult (RPKM 44.4) and 28 other tissues See more
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Genomic context

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See Gm45927 in Genome Data Viewer
Location:
3 F1; 3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89072102..89090077)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89164795..89182770)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29704 Neighboring gene STARR-seq mESC enhancer starr_08224 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Neighboring gene CDC-like kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2079 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene endosomal transmembrane epsin interactor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88994426-88994609 Neighboring gene STARR-positive B cell enhancer ABC_E275 Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Ng P, et al. Nat Methods, 2005 Feb. PMID 15782207
  2. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Readthrough Gm45927

Included genes: Clk2, Scamp3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC105943584
Names
Clk2-scamp3 readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310016.1 → NP_001296945.1  uncharacterized protein LOC105943584 isoform 1

    See identical proteins and their annotated locations for NP_001296945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161600
    UniProtKB/TrEMBL
    B2M0S2
    Conserved Domains (2) summary
    pfam04144
    Location:551 → 726
    SCAMP; SCAMP family
    cl21453
    Location:150 → 439
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001310017.1 → NP_001296946.1  uncharacterized protein LOC105943584 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, resulting in differences in the 5' UTR and translation initiation from a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC161600
    Conserved Domains (2) summary
    pfam04144
    Location:323 → 498
    SCAMP; SCAMP family
    cl21453
    Location:1 → 211
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89072102..89090077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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