PAIP1 poly(A) binding protein interacting protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PAIP1provided by HGNC
Official Full Name: poly(A) binding protein interacting protein 1provided by HGNC
Primary source: HGNC:HGNC:16945
See related: Ensembl:ENSG00000172239 MIM:605184; AllianceGenome:HGNC:16945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (43526267..43557411, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (43778980..43811059, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (43526369..43557513, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.
Title: Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.
High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma.
Title: High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma.
The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Title: The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Paip1 contributes to Pancreatic cancer progression and appears to be a valid prognostic factor of PC
Title: Role of Paip1 on angiogenesis and invasion in pancreatic cancer.
Paip1 was overexpressed in cervical cancer (CC) samples and associated with the adverse outcomes in patients with CC. Its knockdown induced inhibition of cell growth, G2/M arrest and apoptosis in CC cells.
Title: Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon.
Title: Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.
our study demonstrated that Paip1 promotes the growth of breast cancers and could be a prognostic biomarker and therapeutic target
Title: Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker.
Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes.
Title: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.
Title: Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of poly(A) binding protein interacting protein 1 (PAIP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH67717 (e-PCR)
- UniSTS:92236

G34968 (e-PCR)
- UniSTS:117678

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation by host of viral process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_positive_effect viral translation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of mCRD-mediated mRNA stability complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: polyadenylate-binding protein-interacting protein 1

Names: PABC1-interacting protein 1; PABP-interacting protein 1; PAIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006451.5 → NP_006442.2 polyadenylate-binding protein-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_006442.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC114956, BC015937, DB089732

Consensus CDS

CCDS3947.1

UniProtKB/Swiss-Prot

A6NKV8, O60455, Q96B61, Q9BS63, Q9H074

Related

ENSP00000302768.3, ENST00000306846.8

Conserved Domains (2) summary

PRK14951
Location:35 → 123

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

pfam02854
Location:160 → 376

MIF4G; MIF4G domain
NM_182789.4 → NP_877590.1 polyadenylate-binding protein-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_877590.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC114956, AK308270, BC015937

Consensus CDS

CCDS47204.1

UniProtKB/TrEMBL

D6REB4

Related

ENSP00000387729.2, ENST00000436644.6

Conserved Domains (2) summary

pfam07145
Location:45 → 61

PAM2; Ataxin-2 C-terminal region

pfam02854
Location:81 → 297

MIF4G; MIF4G domain
NM_183323.3 → NP_899152.1 polyadenylate-binding protein-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_899152.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, resulting in a different 5' UTR and use of a downstream in-frame start codon. Isoform 3 has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC114956, BC015937, DB089732

Consensus CDS

CCDS3948.1

UniProtKB/TrEMBL

D6REB4

Related

ENSP00000339622.4, ENST00000338972.8

Conserved Domains (2) summary

pfam07145
Location:12 → 28

PAM2; Ataxin-2 C-terminal region

pfam02854
Location:48 → 264

MIF4G; MIF4G domain