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TRIM3 tripartite motif containing 3 [ Homo sapiens (human) ]

Gene ID: 10612, updated on 3-Apr-2024

Summary

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Official Symbol
TRIM3provided by HGNC
Official Full Name
tripartite motif containing 3provided by HGNC
Primary source
HGNC:HGNC:10064
See related
Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BERP; HAC1; RNF22; RNF97
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

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See TRIM3 in Genome Data Viewer
Location:
11p15.4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6448613..6474459, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6507075..6532930, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6469843..6495689, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3102 Neighboring gene hemopexin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4341 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6493832-6494771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6494772-6495710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:6502154-6503353 Neighboring gene ADP ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination. Deng Y, et al. Curr Eye Res, 2022 May. PMID 35317686
  2. Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer. Farhadi J, et al. J Gastrointest Cancer, 2022 Mar. PMID 33415720
  3. Exosomal TRIM3 is a novel marker and therapy target for gastric cancer. Fu H, et al. J Exp Clin Cancer Res, 2018 Jul 21. PMID 30031392, Free PMC Article
  4. Tripartite motif-containing protein 3 plays a role of tumor inhibitor in cervical cancer. Song Y, et al. Biochem Biophys Res Commun, 2018 Apr 6. PMID 29524410
  5. Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer. Huang XQ, et al. Chin J Cancer, 2017 Sep 26. PMID 28950898, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
    Title: Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
  2. TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
    Title: TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
  3. Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
    Title: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
  4. TRIM3 Inhibits H2O2-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
    Title: TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
  5. TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
    Title: TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
  6. Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
    Title: Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
  7. TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
    Title: TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
  8. miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
    Title: miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
  9. Foxo3a exerted inhibitory effects on LPS-induced proliferation and inflammation through increasing TRIM3 transcription.
    Title: Forkhead box o3a suppresses lipopolysaccharide-stimulated proliferation and inflammation in fibroblast-like synoviocytes through regulating tripartite motif-containing protein 3.
  10. after silencing or overexpressing TRIM31 expression, the proliferation, invasion and migration of glioma cells could be downregulated or upregulated through Akt signaling pathway
    Title: TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 3
Names
RING finger protein 97
brain expressed ring finger
brain-expressed RING finger protein
ring finger protein 22
tripartite motif protein TRIM3
NP_001234935.1
NP_001234936.1
NP_006449.2
NP_150594.2
XP_016872587.1
XP_024304096.1
XP_047282213.1
XP_047282214.1
XP_047282215.1
XP_047282217.1
XP_047282218.1
XP_054223451.1
XP_054223452.1
XP_054223453.1
XP_054223454.1
XP_054223455.1
XP_054223456.1
XP_054223457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001248006.2 → NP_001234935.1  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001234935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different 5' UTR, compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000433102.1, ENST00000525074.5
    Conserved Domains (5) summary
    smart00502
    Location:158 → 284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110 → 151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322 → 419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:19 → 63
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

  2. NM_001248007.2 → NP_001234936.1  tripartite motif-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001234936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK291396, AK298843, AK299586, AL122053, BC096827
    Consensus CDS
    CCDS58115.1
    UniProtKB/Swiss-Prot
    O75382
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000445460.1, ENST00000536344.5
    Conserved Domains (4) summary
    smart00502
    Location:39 → 165
    BBC; B-Box C-terminal domain
    smart00557
    Location:203 → 300
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:352 → 625
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cl00034
    Location:2 → 34
    Bbox_SF; B-box-type zinc finger superfamily

  3. NM_006458.4 → NP_006449.2  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_006449.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK291396, AK299586, AL122053, BC096827, BI916995
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000352508.3, ENST00000359518.7
    Conserved Domains (5) summary
    smart00502
    Location:158 → 284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110 → 151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322 → 419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:19 → 63
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

  4. NM_033278.4 → NP_150594.2  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_150594.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AL122053, BC096827, BM758857, DA089323, DA347370, DB344600
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000340797.3, ENST00000345851.8
    Conserved Domains (5) summary
    smart00502
    Location:158 → 284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110 → 151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322 → 419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:19 → 63
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6448613..6474459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426261.1 → XP_047282217.1  tripartite motif-containing protein 3 isoform X4

  2. XM_024448328.2 → XP_024304096.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    UniProtKB/TrEMBL
    B7Z5Y8
    Conserved Domains (5) summary
    smart00502
    Location:158 → 284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110 → 151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322 → 419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:19 → 63
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

  3. XM_017017098.3 → XP_016872587.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    UniProtKB/TrEMBL
    B7Z5Y8
    Conserved Domains (5) summary
    smart00502
    Location:158 → 284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110 → 151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322 → 419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:19 → 63
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

  4. XM_047426258.1 → XP_047282214.1  tripartite motif-containing protein 3 isoform X2

  5. XM_047426257.1 → XP_047282213.1  tripartite motif-containing protein 3 isoform X1

  6. XM_047426259.1 → XP_047282215.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

  7. XM_047426262.1 → XP_047282218.1  tripartite motif-containing protein 3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6507075..6532930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367481.1 → XP_054223456.1  tripartite motif-containing protein 3 isoform X4

  2. XM_054367478.1 → XP_054223453.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

  3. XM_054367479.1 → XP_054223454.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

  4. XM_054367477.1 → XP_054223452.1  tripartite motif-containing protein 3 isoform X2

  5. XM_054367476.1 → XP_054223451.1  tripartite motif-containing protein 3 isoform X1

  6. XM_054367480.1 → XP_054223455.1  tripartite motif-containing protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

  7. XM_054367482.1 → XP_054223457.1  tripartite motif-containing protein 3 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033279.1: Suppressed sequence

    Description
    NM_033279.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75382.2 GenPept UniProtKB/Swiss-Prot:O75382

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