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Txndc11 thioredoxin domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 106200, updated on 5-Mar-2024

Summary

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Official Symbol
Txndc11provided by MGI
Official Full Name
thioredoxin domain containing 11provided by MGI
Primary source
MGI:MGI:1923620
See related
Ensembl:ENSMUSG00000022498 AllianceGenome:MGI:1923620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EFP1; Txdc11; 2810408E11Rik
Summary
Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Orthologous to human TXNDC11 (thioredoxin domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.3), mammary gland adult (RPKM 28.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 6.33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10892775..10952541, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11074911..11134645, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 15 pseudogene Neighboring gene predicted gene 9861 Neighboring gene STARR-positive B cell enhancer ABC_E9926 Neighboring gene STARR-positive B cell enhancer ABC_E10889 Neighboring gene nonconserved acetylation island sequence M94 enhancer Neighboring gene stannin Neighboring gene zinc finger CCCH type containing 7 A Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene predicted gene, 24145 Neighboring gene 40S ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. Moritani M, et al. Genomics, 2006 Dec. PMID 16919419
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thioredoxin domain-containing protein 11
Names
EF-hand binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029582.2 → NP_083858.1  thioredoxin domain-containing protein 11 isoform 1

    See identical proteins and their annotated locations for NP_083858.1

    Status: PROVISIONAL

    Source sequence(s)
    AC087541, AC164093
    Consensus CDS
    CCDS27960.1
    UniProtKB/Swiss-Prot
    Q8BMR8, Q8K2W3, Q8VCK9
    UniProtKB/TrEMBL
    Q3U194
    Related
    ENSMUSP00000041113.8, ENSMUST00000038424.14
    Conserved Domains (5) summary
    cd02981
    Location:215 → 319
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:661 → 763
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03006
    Location:93 → 205
    PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
    pfam08287
    Location:800 → 872
    DASH_Spc19; Spc19
    pfam13848
    Location:254 → 397
    Thioredoxin_6; Thioredoxin-like domain

  2. NM_134105.2 → NP_598866.1  thioredoxin domain-containing protein 11 isoform 2

    See identical proteins and their annotated locations for NP_598866.1

    Status: PROVISIONAL

    Source sequence(s)
    BC019564
    UniProtKB/Swiss-Prot
    Q8K2W3
    Conserved Domains (2) summary
    cd02995
    Location:37 → 139
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    pfam08287
    Location:176 → 248
    DASH_Spc19; Spc19

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10892775..10952541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159724.1 → XP_036015617.1  thioredoxin domain-containing protein 11 isoform X4

    Conserved Domains (3) summary
    COG4942
    Location:485 → 569
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:357 → 459
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:200 → 463
    PTZ00102; disulphide isomerase; Provisional

  2. XM_006521659.4 → XP_006521722.1  thioredoxin domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q3U194
    Conserved Domains (4) summary
    COG4942
    Location:720 → 804
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:592 → 694
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03006
    Location:93 → 205
    PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
    PTZ00102
    Location:435 → 698
    PTZ00102; disulphide isomerase; Provisional

  3. XM_030248911.2 → XP_030104771.1  thioredoxin domain-containing protein 11 isoform X4

    Conserved Domains (3) summary
    COG4942
    Location:485 → 569
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:357 → 459
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:200 → 463
    PTZ00102; disulphide isomerase; Provisional

  4. XM_006521660.5 → XP_006521723.1  thioredoxin domain-containing protein 11 isoform X2

    UniProtKB/TrEMBL
    Q3U194
    Conserved Domains (5) summary
    COG4942
    Location:714 → 798
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:586 → 688
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:429 → 692
    PTZ00102; disulphide isomerase; Provisional
    pfam13848
    Location:166 → 322
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:76 → 130
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  5. XM_006521661.5 → XP_006521724.1  thioredoxin domain-containing protein 11 isoform X3

    See identical proteins and their annotated locations for XP_006521724.1

    Conserved Domains (4) summary
    COG4942
    Location:579 → 663
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:451 → 553
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:294 → 557
    PTZ00102; disulphide isomerase; Provisional
    pfam13848
    Location:31 → 187
    Thioredoxin_6; Thioredoxin-like domain

  6. XM_036159723.1 → XP_036015616.1  thioredoxin domain-containing protein 11 isoform X4

    Conserved Domains (3) summary
    COG4942
    Location:485 → 569
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:357 → 459
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:200 → 463
    PTZ00102; disulphide isomerase; Provisional

  7. XM_006521662.4 → XP_006521725.1  thioredoxin domain-containing protein 11 isoform X3

    See identical proteins and their annotated locations for XP_006521725.1

    Conserved Domains (4) summary
    COG4942
    Location:579 → 663
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:451 → 553
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:294 → 557
    PTZ00102; disulphide isomerase; Provisional
    pfam13848
    Location:31 → 187
    Thioredoxin_6; Thioredoxin-like domain

  8. XM_036159725.1 → XP_036015618.1  thioredoxin domain-containing protein 11 isoform X4

    Conserved Domains (3) summary
    COG4942
    Location:485 → 569
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd02995
    Location:357 → 459
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    PTZ00102
    Location:200 → 463
    PTZ00102; disulphide isomerase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2W3.1 GenPept UniProtKB/Swiss-Prot:Q8K2W3

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