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Rrn3 RRN3 RNA polymerase I transcription factor homolog (yeast) [ Mus musculus (house mouse) ]

Gene ID: 106298, updated on 23-Jun-2021

Summary

Official Symbol
Rrn3provided by MGI
Official Full Name
RRN3 RNA polymerase I transcription factor homolog (yeast)provided by MGI
Primary source
MGI:MGI:1925255
See related
Ensembl:ENSMUSG00000022682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIF-; Tif1a; R75565; TIF-1A; AL023001; E130302O19Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.0), whole brain E14.5 (RPKM 11.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rrn3 in Genome Data Viewer
Location:
16; 16 A1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13598563..13632705)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13780699..13814841)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (13780792..13814934)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930007A09 gene Neighboring gene elongin-B pseudogene Neighboring gene N-terminal Asn amidase Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase I core binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase I general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytoplasm organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleolus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation from RNA polymerase I promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transcription initiation from RNA polymerase I promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA polymerase I-specific transcription initiation factor RRN3
Names
transcription initiation factor TIF-IA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039521.1NP_001034610.1  RNA polymerase I-specific transcription initiation factor RRN3

    See identical proteins and their annotated locations for NP_001034610.1

    Status: VALIDATED

    Source sequence(s)
    AA437536, AK165676, BC034110, BC055781, CJ175904
    Consensus CDS
    CCDS27968.1
    UniProtKB/Swiss-Prot
    B2RS91
    Related
    ENSMUSP00000023363.7, ENSMUST00000023363.8
    Conserved Domains (1) summary
    pfam05327
    Location:58581
    RRN3; RNA polymerase I specific transcription initiation factor RRN3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13598563..13632705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159727.1XP_036015620.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X1

    Conserved Domains (1) summary
    pfam05327
    Location:3484
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
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