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Cd8_civ Cd8 alpha DNase I hypersensitive cluster CIV [ Mus musculus (house mouse) ]

Gene ID: 106699572, updated on 8-Feb-2024

Summary

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Gene symbol
Cd8_civ
Gene description
Cd8 alpha DNase I hypersensitive cluster CIV
Gene type
biological region
Feature type(s)
misc_feature: conserved_region
protein_bind
regulatory: DNase_I_hypersensitive_site, enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E8II; E8IV; E8VI; CD8DP; E8III
Summary
This region contains multiple conserved elements and DNase I hypersensitive sites overlapping with enhancers of the Cd8a (CD8a molecule) gene. Enhancer fragments in this region direct expression to different T cell lineages, including DP thermocytes and mature CD8+ T cells. These sequences may synergize with enhancers located nearby in the CII and CIII DNase I hypersensitive regions. Binding by the POZ (BTB) and AT hook containing zinc finger 1 protein suppresses enhancer activity, causing variegated expression. A subregion was identified as a candidate cis-regulatory module (CRM) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. That subregion was validated as an enhancer by high-throughput CapStarr-seq reporter assays showing weak activity in P5424 T cells. [provided by RefSeq, Mar 2023]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71306536..71320625)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71329552..71343641)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16261 Neighboring gene predicted gene 1070 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71266617-71266800 Neighboring gene predicted gene, 38828 Neighboring gene CD8 subunit beta 1 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene CD8 subunit alpha Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene required for meiotic nuclear division 5 homolog A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SATB1 is required for CD8 coreceptor reversal. Nie H, et al. Mol Immunol, 2008 Nov. PMID 18722016, Free PMC Article
  2. T cell development: bottoms-up. Hedrick SM. Immunity, 2002 May. PMID 12049714
  3. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Ellmeier W, et al. Annu Rev Immunol, 1999. PMID 10358767
  4. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Ellmeier W, et al. Immunity, 1998 Oct. PMID 9806635
  5. Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. Zhang S, et al. J Exp Med, 2010 Aug 2. PMID 20660613, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • CapStarr-seq enhancer MGSCv37_chr6:71283160-71283392
  • Cd8 enhancer elements E8(II), E8(III), and E8(IV)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044965.1 

    Range
    101..14190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71306536..71320625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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