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Hmgxb3 HMG box domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 106894, updated on 21-Apr-2024

Summary

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Official Symbol
Hmgxb3provided by MGI
Official Full Name
HMG box domain containing 3provided by MGI
Primary source
MGI:MGI:2441817
See related
Ensembl:ENSMUSG00000024622 AllianceGenome:MGI:2441817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0194; 2510002C16Rik; A630042L21Rik
Summary
Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human HMGXB3 (HMG-box containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.8), adrenal adult (RPKM 11.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 34.41 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61264349..61310122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61131277..61177050, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene platelet derived growth factor receptor, beta polypeptide Neighboring gene Csf1r promoter/intronic regulatory region Neighboring gene colony stimulating factor 1 receptor Neighboring gene microRNA 6983 Neighboring gene predicted gene, 26403 Neighboring gene predicted gene, 50614 Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene ribosomal protein S2, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Tan D, et al. Nat Struct Mol Biol, 2014 Aug. PMID 25026078, Free PMC Article
  2. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
HMG domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134134.2 → NP_598895.2  HMG domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_598895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB045322, AK041866, AK132529, BC025148, BG061435, BU611563
    Consensus CDS
    CCDS50301.1
    UniProtKB/TrEMBL
    G3X9M3, Q6PEF4
    Related
    ENSMUSP00000089498.5, ENSMUST00000091884.6
    Conserved Domains (1) summary
    smart00398
    Location:40 → 99
    HMG; high mobility group

  2. NM_178277.1 → NP_840061.1  HMG domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_840061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
    Source sequence(s)
    AB045322, BC025148, BC058089
    Consensus CDS
    CCDS89249.1
    UniProtKB/TrEMBL
    Q6AXF8, Q6PEF4
    Related
    ENSMUSP00000158376.2, ENSMUST00000235480.2
    Conserved Domains (1) summary
    smart00398
    Location:40 → 99
    HMG; high mobility group

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61264349..61310122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317779.1 → XP_017173268.1  HMG domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    Q6NZP6, Q9JJ64
    Conserved Domains (1) summary
    pfam18717
    Location:318 → 392
    CxC4; CxC4 like cysteine cluster associated with KDZ transposases
Nucleotide Protein Strain
Heading Accession and Version

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