ORS8 origin-enriched sequence 8 [Homo sapiens (human)] - Gene

Summary

Gene symbol: ORS8
Gene description: origin-enriched sequence 8
Gene type: biological region
Feature type(s): protein_bind
rep_origin
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This region represents an origin of DNA replication that was first identified in African green monkey cells. Unlike the monkey origin, which replicates early, this human sequence replicates late in S phase. This sequence recognizes and binds Ku80 protein (X-ray repair complementing defective repair in Chinese hamster cells 5) during G1 phase, which recruits topoisomerase (DNA) II beta and results in transient double-strand breaks in this region. These breaks are important for recruitment of additional proteins involved in origin activity, including origin recognition complex subunit 2, chromatin licensing and DNA replication factor 1, and cell division cycle 45. [provided by RefSeq, Jan 2016]
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Genomic context

Location:: chromosome: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (37078248..37078572)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (37218592..37218916)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (37117853..37118177)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

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General gene information

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Other Names

human homolog of monkey replication origin ors8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.