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Btaf1 B-TFIID TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 107182, updated on 5-Mar-2024

Summary

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Official Symbol
Btaf1provided by MGI
Official Full Name
B-TFIID TATA-box binding protein associated factor 1provided by MGI
Primary source
MGI:MGI:2147538
See related
Ensembl:ENSMUSG00000040565 AllianceGenome:MGI:2147538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAF170; E430027O22Rik
Summary
Predicted to enable ATP-dependent activity, acting on DNA; DNA binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of chromatin binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human BTAF1 (B-TFIID TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.3), liver E14 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 32.02 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36903479..36991457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36926079..37014057)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Neighboring gene STARR-seq mESC enhancer starr_46034 Neighboring gene VISTA enhancer mm1641 Neighboring gene STARR-seq mESC enhancer starr_46037 Neighboring gene STARR-positive B cell enhancer ABC_E11029 Neighboring gene STARR-seq mESC enhancer starr_46040 Neighboring gene STARR-positive B cell enhancer ABC_E4277 Neighboring gene STARR-seq mESC enhancer starr_46041 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene RIKEN cDNA A330032B11 gene Neighboring gene membrane associated ring-CH-type finger 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Wansleeben C, et al. Mech Dev, 2011 May-Jun. PMID 21419221
  2. Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals. Xue Y, et al. Mol Cell, 2017 Aug 17. PMID 28735899, Free PMC Article
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
    Title: Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.
  2. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability
    Title: An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TATA-binding protein-associated factor 172
Names
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, (Mot1 homolog, S. cerevisiae)
TBP-associated factor 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080706.1 → NP_001074175.1  TATA-binding protein-associated factor 172

    Status: PROVISIONAL

    Source sequence(s)
    AC118931
    Consensus CDS
    CCDS37969.1
    UniProtKB/TrEMBL
    A0ZVB6, E9QAE3
    Related
    ENSMUSP00000097093.4, ENSMUST00000099494.4
    Conserved Domains (6) summary
    cd00046
    Location:1285 → 1434
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:1268 → 1584
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1643 → 1743
    Helicase_C; Helicase conserved C-terminal domain
    pfam12054
    Location:585 → 1050
    DUF3535; Domain of unknown function (DUF3535)
    pfam13513
    Location:402 → 453
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:351 → 376
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    36903479..36991457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161373.1 → XP_036017266.1  TATA-binding protein-associated factor 172 isoform X1

    UniProtKB/TrEMBL
    A0ZVB6
    Conserved Domains (4) summary
    COG0553
    Location:1073 → 1645
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:196 → 221
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:1110 → 1347
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:430 → 895
    DUF3535; Domain of unknown function (DUF3535)

  2. XM_006526561.5 → XP_006526624.1  TATA-binding protein-associated factor 172 isoform X2

    UniProtKB/TrEMBL
    A0ZVB6
    Conserved Domains (4) summary
    COG0553
    Location:1026 → 1598
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:149 → 174
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:1063 → 1300
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:383 → 848
    DUF3535; Domain of unknown function (DUF3535)

  3. XM_030250684.2 → XP_030106544.1  TATA-binding protein-associated factor 172 isoform X3

    UniProtKB/TrEMBL
    Q52KH4
    Conserved Domains (4) summary
    COG0553
    Location:456 → 1028
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:335 → 363
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:493 → 730
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:1 → 278
    DUF3535; Domain of unknown function (DUF3535)

  4. XM_017318039.3 → XP_017173528.1  TATA-binding protein-associated factor 172 isoform X3

    UniProtKB/TrEMBL
    Q52KH4
    Conserved Domains (4) summary
    COG0553
    Location:456 → 1028
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:335 → 363
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:493 → 730
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:1 → 278
    DUF3535; Domain of unknown function (DUF3535)
Nucleotide Protein Strain
Heading Accession and Version

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