PLK2 polo like kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLK2provided by HGNC
Official Full Name: polo like kinase 2provided by HGNC
Primary source: HGNC:HGNC:19699
See related: Ensembl:ENSG00000145632 MIM:607023; AllianceGenome:HGNC:19699
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SNK; hSNK; hPlk2
Summary: The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression: Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q11.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (58453982..58460086, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (59272431..59278533, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (57749809..57755913, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.
Title: Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.
Combination of FOXD1 and Plk2: A novel biomarker for predicting unfavourable prognosis of colorectal cancer.
Title: Combination of FOXD1 and Plk2: A novel biomarker for predicting unfavourable prognosis of colorectal cancer.
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.
Title: Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.
Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.
Title: Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Title: Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.
Title: Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.
Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.
Title: Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.
Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling.
Title: Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling.
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of alpha-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Title: Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
There were aberrant expressions of miR-27b and PLK2 in oral lichen planus tissues. Decreased miR-27b may have induced cell proliferation by increasing the levels of PLK2 in oral keratinocytes.
Title: Downregulated miR-27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HSC1XG062 (e-PCR)
- UniSTS:77332

IB1671 (e-PCR)
- UniSTS:11036

PLK2 (e-PCR)
- UniSTS:505753

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS Traceable Author Statement more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process in bone marrow cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	HMP more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centriole replication	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK2

Names: PLK-2; serine/threonine-protein kinase SNK; serum-inducible kinase

NP_001239155.1

EC 2.7.11.21

NP_006613.2

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252226.2 → NP_001239155.1 serine/threonine-protein kinase PLK2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1, however, it maintains the reading frame and encodes a shorter isoform (2) missing a 14 aa protein segment compared to isoform 1.

Source sequence(s)

AA954432, AK027851, BC013879, N66865

Consensus CDS

CCDS75250.1

UniProtKB/TrEMBL

A0A087WUH9

Related

ENSP00000478685.1, ENST00000617412.1

Conserved Domains (4) summary

smart00220
Location:68 → 320

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:587 → 668

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:489 → 574

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14188
Location:66 → 320

STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2
NM_006622.4 → NP_006613.2 serine/threonine-protein kinase PLK2 isoform 1

See identical proteins and their annotated locations for NP_006613.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).

Source sequence(s)

AA954432, AK027851, BC013879, N66865

Consensus CDS

CCDS3974.1

UniProtKB/Swiss-Prot

O60679, Q96CV7, Q9NYY3, Q9UE61

Related

ENSP00000274289.3, ENST00000274289.8

Conserved Domains (3) summary

cd13117
Location:601 → 682

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:503 → 588

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14188
Location:80 → 334

STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2