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ZNF268 zinc finger protein 268 [ Homo sapiens (human) ]

Gene ID: 10795, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF268provided by HGNC
Official Full Name
zinc finger protein 268provided by HGNC
Primary source
HGNC:HGNC:13061
See related
Ensembl:ENSG00000090612 MIM:604753; AllianceGenome:HGNC:13061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of nitrogen compound metabolic process; and regulation of apoptotic process. Located in actin cytoskeleton; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 5.9), kidney (RPKM 4.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF268 in Genome Data Viewer
Location:
12q24.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133181495..133214832)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133238807..133272083)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133758081..133791418)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7400 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26228 Neighboring gene zinc finger protein 10 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:133731795-133732994 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133757799-133758323 Neighboring gene anomalous homeobox Neighboring gene RNA, U6 small nuclear 717, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly. Liu Y, et al. Cells, 2019 Dec 10. PMID 31835635, Free PMC Article
  2. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Hu L, et al. Oncol Lett, 2013 Jul. PMID 23946776, Free PMC Article
  3. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Zhao Z, et al. Oncol Rep, 2008 Nov. PMID 18949428
  4. A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha. Chun JN, et al. Mol Cells, 2008 Aug 31. PMID 18677094
  5. KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. Shao H, et al. Int J Mol Med, 2006 Sep. PMID 16865230

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
    Title: KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
  2. The nuclear localization activity of KRAB domain is a conserved feature of ZNF268.
    Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
  3. These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling.
    Title: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.
  4. ZNF268 is a crucial downstream target and effector of GATA-1
    Title: Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.
  5. 4 alternative transcripts of ZNF268 were detected in the human blood cells.
    Title: [Cloning and characterization of two novel alternatively spliced transcripts of ZNF268].
  6. aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies.
    Title: Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.
  7. results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex.
    Title: A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.
  8. Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter.
    Title: The mammalian gene ZNF268 is regulated by hUpf1.
  9. HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding
    Title: Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.
  10. This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity.
    Title: The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ZNF10

Homology

Clone Names

  • MGC126498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 268
Names
zinc finger protein 3
zinc finger protein HZF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165881.3 → NP_001159353.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_001159353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AW138703, BC110542, KF455750
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587, Q8TDG8, Q96RH4, Q9BZJ9
    Related
    ENSP00000228289.5, ENST00000228289.9
    Conserved Domains (6) summary
    smart00349
    Location:81 → 141
    KRAB; krueppel associated box
    COG5048
    Location:497 → 910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:558 → 578
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:556 → 578
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:81 → 120
    KRAB; KRAB box
    pfam13465
    Location:710 → 734
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001165882.3 → NP_001159354.1  zinc finger protein 268 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC026786, AC226150, AW138703, BC110542, CN255799, KF455750
    UniProtKB/TrEMBL
    Q2TB61
    Conserved Domains (6) summary
    smart00349
    Location:2 → 58
    KRAB; krueppel associated box
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:475 → 495
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:473 → 495
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2 → 37
    KRAB; KRAB box
    pfam13465
    Location:627 → 651
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001165883.2 → NP_001159355.1  zinc finger protein 268 isoform d

    See identical proteins and their annotated locations for NP_001159355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, BC058548, KF455750
    Consensus CDS
    CCDS59240.1
    UniProtKB/Swiss-Prot
    Q14587
    Related
    ENSP00000467781.1, ENST00000539248.6

  4. NM_001165884.3 → NP_001159356.2  zinc finger protein 268 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF432217, AW138703, KF455750
    Consensus CDS
    CCDS53854.1
    UniProtKB/TrEMBL
    F5H1T2
    Related
    ENSP00000438941.1, ENST00000536899.6

  5. NM_001165885.2 → NP_001159357.1  zinc finger protein 268 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (f) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057356, KF455750
    Consensus CDS
    CCDS53851.1
    UniProtKB/TrEMBL
    F5H7L3
    Related
    ENSP00000442446.2, ENST00000541211.6

  6. NM_001165886.2 → NP_001159358.1  zinc finger protein 268 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057357, KF455750
    Consensus CDS
    CCDS53853.1
    UniProtKB/TrEMBL
    F5H670
    Related
    ENSP00000437858.1, ENST00000542711.6

  7. NM_001165887.2 → NP_001159359.1  zinc finger protein 268 isoform h

    See identical proteins and their annotated locations for NP_001159359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon and contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (h) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DB079580, DQ057360, KF455750
    Consensus CDS
    CCDS53852.1
    UniProtKB/TrEMBL
    A0A087WV54, K7EQP6
    Related
    ENSP00000467922.1, ENST00000592241.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box

  8. NM_003415.3 → NP_003406.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_003406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AF317549, KF455750
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587, Q8TDG8, Q96RH4, Q9BZJ9
    Related
    ENSP00000444412.3, ENST00000536435.7
    Conserved Domains (6) summary
    smart00349
    Location:81 → 141
    KRAB; krueppel associated box
    COG5048
    Location:497 → 910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:558 → 578
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:556 → 578
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:81 → 120
    KRAB; KRAB box
    pfam13465
    Location:710 → 734
    zf-H2C2_2; Zinc-finger double domain

  9. NM_152943.3 → NP_694422.2  zinc finger protein 268 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF385187, KF455750
    Consensus CDS
    CCDS59239.1
    UniProtKB/TrEMBL
    A0A075B6T9, E7EV44, H3BUM2
    Related
    ENSP00000439539.2, ENST00000541009.6
    Conserved Domains (2) summary
    smart00349
    Location:81 → 141
    KRAB; krueppel associated box
    pfam01352
    Location:81 → 120
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    133181495..133214832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    133238807..133272083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14587.2 GenPept UniProtKB/Swiss-Prot:Q14587

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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