U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SPEM3 SPEM family member 3 [ Homo sapiens (human) ]

Gene ID: 107983988, updated on 14-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SPEM3provided by HGNC
Official Full Name
SPEM family member 3provided by HGNC
Primary source
HGNC:HGNC:53651
See related
Ensembl:ENSG00000283439 AllianceGenome:HGNC:53651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 23.1) See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7428857..7432820)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7332911..7336874)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7332176..7336139)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646 Neighboring gene spermatid maturation 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7329870-7330371 Neighboring gene SPEM family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7339659-7340568 Neighboring gene transmembrane protein 102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7341479-7342387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7342641-7343174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8120 Neighboring gene fibroblast growth factor 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm individualization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein SPEM3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364672.1 → NP_001351601.1  uncharacterized protein SPEM3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113189, HY033016
    Conserved Domains (2) summary
    cl26386
    Location:222 → 405
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl28087
    Location:184 → 654
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001364708.1 → NP_001351637.1  uncharacterized protein SPEM3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113189, HY033016
    Consensus CDS
    CCDS92248.1
    UniProtKB/Swiss-Prot
    A0A1B0GUW6
    Related
    ENSP00000490274.1, ENST00000636696.4
    Conserved Domains (2) summary
    cl26386
    Location:255 → 438
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl28087
    Location:217 → 687
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7428857..7432820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p14 PATCHES

    Range
    49314..53277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7332911..7336874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GUW6.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GUW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials