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Fxyd4 FXYD domain-containing ion transport regulator 4 [ Mus musculus (house mouse) ]

Gene ID: 108017, updated on 23-Jun-2021

Summary

Official Symbol
Fxyd4provided by MGI
Official Full Name
FXYD domain-containing ion transport regulator 4provided by MGI
Primary source
MGI:MGI:1889005
See related
Ensembl:ENSMUSG00000004988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chi; Chif; AI267073; 0610008I02Rik
Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney adult (RPKM 19.0), ovary adult (RPKM 6.9) and 3 other tissues See more
Orthologs
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Genomic context

See Fxyd4 in Genome Data Viewer
Location:
6; 6 F1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117910519..117914668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117933558..117937714, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (117883577..117887353, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene heterogeneous nuclear ribonucleoprotein F Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene RasGEF domain family, member 1A Neighboring gene microRNA 7044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107631

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FXYD domain-containing ion transport regulator 4
Names
channel inducing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173372.1NP_001166843.1  FXYD domain-containing ion transport regulator 4 precursor

    See identical proteins and their annotated locations for NP_001166843.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018728, AU041511
    Consensus CDS
    CCDS20468.1
    UniProtKB/Swiss-Prot
    Q9D2W0
    Related
    ENSMUSP00000145302.2, ENSMUST00000204214.3
    Conserved Domains (1) summary
    pfam02038
    Location:2570
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
  2. NM_033648.1NP_387468.1  FXYD domain-containing ion transport regulator 4 precursor

    See identical proteins and their annotated locations for NP_387468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018728, BC086918
    Consensus CDS
    CCDS20468.1
    UniProtKB/Swiss-Prot
    Q9D2W0
    Related
    ENSMUSP00000005114.8, ENSMUST00000005114.10
    Conserved Domains (1) summary
    pfam02038
    Location:2570
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117910519..117914668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505295.5XP_006505358.1  FXYD domain-containing ion transport regulator 4 isoform X2

    See identical proteins and their annotated locations for XP_006505358.1

    UniProtKB/Swiss-Prot
    Q9D2W0
    Related
    ENSMUSP00000144700.2, ENSMUST00000203082.3
    Conserved Domains (1) summary
    pfam02038
    Location:2570
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
  2. XM_017321297.3XP_017176786.1  FXYD domain-containing ion transport regulator 4 isoform X1

    Conserved Domains (1) summary
    pfam02038
    Location:89134
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
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