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Baiap2 brain-specific angiogenesis inhibitor 1-associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 108100, updated on 5-Jan-2022

Summary

Official Symbol
Baiap2provided by MGI
Official Full Name
brain-specific angiogenesis inhibitor 1-associated protein 2provided by MGI
Primary source
MGI:MGI:2137336
See related
Ensembl:ENSMUSG00000025372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRSp53; R75030
Summary
Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and scaffold protein binding activity. Involved in several processes, including actin filament organization; modification of synaptic structure, modulating synaptic transmission; and regulation of cell shape. Acts upstream of or within dendrite development and regulation of synaptic plasticity. Located in Schaffer collateral - CA1 synapse and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 31.0), cortex adult (RPKM 30.6) and 27 other tissues See more
Orthologs
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Genomic context

See Baiap2 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119833762..119897608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119939916..120006782)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (119804406..119868096)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39485 Neighboring gene charged multivesicular body protein 6 Neighboring gene uncharacterized LOC118567883 Neighboring gene predicted gene 11767 Neighboring gene apoptosis-associated tyrosine kinase Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal anchor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin crosslink formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament bundle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modification of synaptic structure, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modification of synaptic structure, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection branch point ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
brain-specific angiogenesis inhibitor 1-associated protein 2
Names
BAI-associated protein 2
BAI1-associated protein 2
insulin receptor substrate p53
insulin receptor substrate protein of 53 kDa
insulin receptor tyrosine kinase 53 kDa substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037754.3NP_001032843.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform c

    See identical proteins and their annotated locations for NP_001032843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AF390179, AK145924, AL953913
    Consensus CDS
    CCDS25723.1
    UniProtKB/Swiss-Prot
    Q8BKX1
    UniProtKB/TrEMBL
    Q3UKP6
    Related
    ENSMUSP00000099310.4, ENSMUST00000103021.10
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:338396
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  2. NM_001037755.3NP_001032844.2  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform a

    See identical proteins and their annotated locations for NP_001032844.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK049469, AK145924, CO039918
    Consensus CDS
    CCDS25722.1
    UniProtKB/Swiss-Prot
    Q8BKX1
    UniProtKB/TrEMBL
    Q3UKP6
    Related
    ENSMUSP00000026436.4, ENSMUST00000026436.10
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. NM_130862.4NP_570932.2  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform b

    See identical proteins and their annotated locations for NP_570932.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL929234, AL953913
    Consensus CDS
    CCDS25724.1
    UniProtKB/Swiss-Prot
    Q8BKX1
    UniProtKB/TrEMBL
    Q3UKP6
    Related
    ENSMUSP00000074674.6, ENSMUST00000075180.12
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119833762..119897608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531966.5XP_006532029.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006532029.1

    UniProtKB/TrEMBL
    B1AZ46
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  2. XM_006531967.5XP_006532030.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006532030.1

    UniProtKB/TrEMBL
    B1AZ46
    Related
    ENSMUSP00000101840.2, ENSMUST00000106233.2
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  3. XM_006531968.5XP_006532031.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006532031.1

    UniProtKB/TrEMBL
    B1AZ46
    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:378436
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  4. XM_036156221.1XP_036012114.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:338396
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
  5. XM_006531969.5XP_006532032.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

    Conserved Domains (2) summary
    cd07646
    Location:5236
    I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
    cd11915
    Location:338396
    SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
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