U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fermt3 fermitin family member 3 [ Mus musculus (house mouse) ]

Gene ID: 108101, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fermt3provided by MGI
Official Full Name
fermitin family member 3provided by MGI
Primary source
MGI:MGI:2147790
See related
Ensembl:ENSMUSG00000024965 AllianceGenome:MGI:2147790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kindlin3
Summary
Enables integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Located in podosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 110.9), spleen adult (RPKM 102.1) and 13 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19 A; 19 5.13 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6976326..6996837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6998958..7019469, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones. Klapproth S, et al. J Cell Sci, 2021 Nov 15. PMID 34704600
  2. Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. Ni T, et al. Biochem J, 2017 Feb 15. PMID 27974389, Free PMC Article
  3. Interaction of kindlin-3 and β2-integrins differentially regulates neutrophil recruitment and NET release in mice. Xu Z, et al. Blood, 2015 Jul 16. PMID 26056166
  4. Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Moretti FA, et al. Proc Natl Acad Sci U S A, 2013 Oct 15. PMID 24089451, Free PMC Article
  5. The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis. Cohen SJ, et al. Blood, 2013 Oct 10. PMID 23980064

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
    Title: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
  2. Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
    Title: Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
  3. Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
    Title: Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
  4. Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
    Title: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
  5. Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
    Title: Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
  6. Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
    Title: Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
  7. Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
    Title: Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
  8. Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
    Title: Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
  9. Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
    Title: Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
  10. The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.
    Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC36836, MGC38286

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell-cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell-substrate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
fermitin family homolog 3
Names
unc-112-related protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362399.1 → NP_001349328.1  fermitin family homolog 3

    Status: VALIDATED

    Source sequence(s)
    AC120557, AC163098
    Consensus CDS
    CCDS29518.1
    UniProtKB/Swiss-Prot
    Q8K1B8
    UniProtKB/TrEMBL
    Q3TEE6
    Conserved Domains (4) summary
    smart00295
    Location:221 → 301
    B41; Band 4.1 homologues
    cd01237
    Location:350 → 474
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:550 → 641
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00373
    Location:490 → 555
    FERM_M; FERM central domain

  2. NM_153795.2 → NP_722490.1  fermitin family homolog 3

    See identical proteins and their annotated locations for NP_722490.1

    Status: VALIDATED

    Source sequence(s)
    AC163098, AK142912
    Consensus CDS
    CCDS29518.1
    UniProtKB/Swiss-Prot
    Q8K1B8
    UniProtKB/TrEMBL
    Q3TEE6
    Related
    ENSMUSP00000037858.9, ENSMUST00000040772.9
    Conserved Domains (4) summary
    smart00295
    Location:221 → 301
    B41; Band 4.1 homologues
    cd01237
    Location:350 → 474
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:550 → 641
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00373
    Location:490 → 555
    FERM_M; FERM central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6976326..6996837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1B8.1 GenPept UniProtKB/Swiss-Prot:Q8K1B8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous