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npas4l neuronal PAS domain protein 4 like [ Danio rerio (zebrafish) ]

Gene ID: 108449885, updated on 25-Jan-2022

Summary

Official Symbol
npas4lprovided by ZNC
Official Full Name
neuronal PAS domain protein 4 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070117-2515
See related
Ensembl:ENSDARG00000116511 AllianceGenome:ZFIN:ZDB-GENE-070117-2515
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
clo
Summary
This gene encodes a PAS-domain-containing basic helix-loop-helix transcription factor. This gene is expressed during late gastrulation and functions as an essential transcriptional regulator of mesoderm diversification and differentiation. The encoded protein is involved in directing the specification of endothelial and haematopoietic cell lineages. Mutations in this genes result in a loss of endothelial and haematopoietic cells and an increase in cardiomyocyte numbers. This gene is located in the telomeric region of chromosome 13. [provided by RefSeq, Aug 2016]
Orthologs
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Genomic context

See npas4l in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (52006945..52014610)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene type I inositol 1,4,5-trisphosphate 5-phosphatase Neighboring gene kinesin light chain 1b Neighboring gene solute carrier family 30 member 10 Neighboring gene kelch domain containing 3 Neighboring gene transmembrane protein 121-like Neighboring gene L-threonine ammonia-lyase-like

Genomic regions, transcripts, and products

Genomic Sequence:
NC_007124.7 Chromosome 13 Reference GRCz11 Primary Assembly

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal PAS domain-containing protein 4-like
Names
cloche
protein cloche

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329912.1NP_001316841.1  neuronal PAS domain-containing protein 4-like

    Status: PROVISIONAL

    Source sequence(s)
    KX066019
    UniProtKB/Swiss-Prot
    P0DOC7
    Related
    ENSDARP00000151859.1, ENSDART00000181259.1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    52006945..52014610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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