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Btg2r3 Btg2R3 erythroid cis-regulatory module [ Mus musculus (house mouse) ]

Gene ID: 108511954, updated on 8-Feb-2024

Summary

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Gene symbol
Btg2r3
Gene description
Btg2R3 erythroid cis-regulatory module
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366717
Summary
This genomic element is located in the intergenic region between the Fmod (fibromodulin) and Btg2 (B cell translocation gene 2, anti-proliferative) genes on chromosome 1. It was predicted to be a cis-regulatory module (preCRM) based on conservation of consensus binding motifs for the essential erythroid transcription factor GATA1, and on distinctive alignment patterns that yielded a positive regulatory potential score. It was validated as a functional enhancer by reporter assays in stably transfected murine erythroleukemia (MEL) cells. [provided by RefSeq, Aug 2016]
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Genomic context

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Location:
1 E4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134000914..134001064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134073176..134073326)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene fibromodulin Neighboring gene STARR-positive B cell enhancer ABC_E5804 Neighboring gene VISTA enhancer mm1445 Neighboring gene predicted gene, 19497 Neighboring gene STARR-positive B cell enhancer ABC_E992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135968249-135968432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135974032-135974219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135974224-135974473 Neighboring gene STARR-positive B cell enhancer ABC_E5805 Neighboring gene STARR-seq mESC enhancer starr_02315 Neighboring gene BTG anti-proliferation factor 2 Neighboring gene predicted gene, 31974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Wang H, et al. Genome Res, 2006 Dec. PMID 17038566, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • Btg2R3 erythroid enhancer
  • Btg2R3 preCRM
  • regulatory region 366717

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051406.1 

    Range
    101..251
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134000914..134001064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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