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Zdhhc15 zinc finger, DHHC domain containing 15 [ Mus musculus (house mouse) ]

Gene ID: 108672, updated on 21-Apr-2024

Summary

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Official Symbol
Zdhhc15provided by MGI
Official Full Name
zinc finger, DHHC domain containing 15provided by MGI
Primary source
MGI:MGI:1915336
See related
Ensembl:ENSMUSG00000033906 AllianceGenome:MGI:1915336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030457O13Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Acts upstream of or within establishment of protein localization; protein palmitoylation; and synaptic vesicle maturation. Located in Golgi apparatus. Is expressed in eye. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 91. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 3.1), CNS E11.5 (RPKM 2.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 46.69 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (103580575..103714696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (104536969..104671090, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47713 Neighboring gene STARR-seq mESC enhancer starr_47714 Neighboring gene predicted gene, 22430 Neighboring gene STARR-seq mESC enhancer starr_47715 Neighboring gene predicted gene, 39530 Neighboring gene STARR-seq mESC enhancer starr_47716 Neighboring gene STARR-seq mESC enhancer starr_47717 Neighboring gene STARR-seq mESC enhancer starr_47718 Neighboring gene RIKEN cDNA 1700121L16 gene Neighboring gene MAGE family member E2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Greaves J, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167757, Free PMC Article
  2. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J, et al. J Biol Chem, 2008 Sep 5. PMID 18596047, Free PMC Article
  3. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
  4. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  5. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-myristoyltransferase activity IC
Inferred by Curator
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IC
Inferred by Curator
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-stearoyltransferase activity IC
Inferred by Curator
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to postsynapse ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic vesicle maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within synaptic vesicle maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC15
Names
DHHC-15
acyltransferase ZDHHC15
zinc finger DHHC domain-containing protein 15
NP_780567.1
XP_011245807.1
XP_011245808.1
XP_017173831.1
XP_036017665.1
XP_036017666.1
XP_036017667.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175358.4 → NP_780567.1  palmitoyltransferase ZDHHC15

    See identical proteins and their annotated locations for NP_780567.1

    Status: VALIDATED

    Source sequence(s)
    AK077949, AK132304, AL731717, BY652237
    Consensus CDS
    CCDS30332.1
    UniProtKB/Swiss-Prot
    Q3TV63, Q8BGJ0, Q8BMB7
    Related
    ENSMUSP00000047615.6, ENSMUST00000042070.6
    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    103580575..103714696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247506.1 → XP_011245808.1  palmitoyltransferase ZDHHC15 isoform X2

    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    DHHC; DHHC palmitoyltransferase

  2. XM_011247505.1 → XP_011245807.1  palmitoyltransferase ZDHHC15 isoform X1

    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    DHHC; DHHC palmitoyltransferase

  3. XM_036161774.1 → XP_036017667.1  palmitoyltransferase ZDHHC15 isoform X6

    Conserved Domains (1) summary
    cl19890
    Location:20 → 199
    DHHC; DHHC palmitoyltransferase

  4. XM_017318342.3 → XP_017173831.1  palmitoyltransferase ZDHHC15 isoform X5

    Conserved Domains (1) summary
    cl19890
    Location:20 → 199
    DHHC; DHHC palmitoyltransferase

  5. XM_036161773.1 → XP_036017666.1  palmitoyltransferase ZDHHC15 isoform X4

    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    DHHC; DHHC palmitoyltransferase

  6. XM_036161772.1 → XP_036017665.1  palmitoyltransferase ZDHHC15 isoform X3

    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGJ0.1 GenPept UniProtKB/Swiss-Prot:Q8BGJ0

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