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Gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Mus musculus (house mouse) ]

Gene ID: 108682, updated on 5-Jan-2022

Summary

Official Symbol
Gpt2provided by MGI
Official Full Name
glutamic pyruvate transaminase (alanine aminotransferase) 2provided by MGI
Primary source
MGI:MGI:1915391
See related
Ensembl:ENSMUSG00000031700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALT2; C87201; AU014768; AU041193; 4631422C05Rik
Summary
Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Predicted to be involved in 2-oxoglutarate metabolic process and L-alanine metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; musculature; nervous system; respiratory system; and sensory organ. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in liver adult (RPKM 35.8), subcutaneous fat pad adult (RPKM 28.6) and 23 other tissues See more
Orthologs
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Genomic context

See Gpt2 in Genome Data Viewer
Location:
8; 8 C3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86219090..86255531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85492576..85528902)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (88016516..88051457)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921524J17 gene Neighboring gene predicted gene, 53446 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2 Neighboring gene predicted gene, 51583

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in L-alanine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
alanine aminotransferase 2
Names
glutamate pyruvate transaminase 2
glutamic--alanine transaminase 2
glutamic--pyruvic transaminase 2
NP_776291.1
XP_006530622.1
XP_036009604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173866.4NP_776291.1  alanine aminotransferase 2

    See identical proteins and their annotated locations for NP_776291.1

    Status: VALIDATED

    Source sequence(s)
    AC130533
    Consensus CDS
    CCDS22499.1
    UniProtKB/Swiss-Prot
    Q8BGT5
    Related
    ENSMUSP00000034136.6, ENSMUST00000034136.12
    Conserved Domains (2) summary
    cd00609
    Location:123512
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:48522
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    86219090..86255531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153711.1XP_036009604.1  alanine aminotransferase 2 isoform X1

    Conserved Domains (1) summary
    PTZ00377
    Location:5379
    PTZ00377; alanine aminotransferase; Provisional
  2. XM_006530559.4XP_006530622.1  alanine aminotransferase 2 isoform X2

    Conserved Domains (1) summary
    PTZ00377
    Location:39290
    PTZ00377; alanine aminotransferase; Provisional

RNA

  1. XR_004934746.1 RNA Sequence

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