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Chn1 chimerin 1 [ Mus musculus (house mouse) ]

Gene ID: 108699, updated on 23-Jun-2021

Summary

Official Symbol
Chn1provided by MGI
Official Full Name
chimerin 1provided by MGI
Primary source
MGI:MGI:1915674
See related
Ensembl:ENSMUSG00000056486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARH; ARHGAP2; AI413815; 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik
Expression
Biased expression in cortex adult (RPKM 122.5), frontal lobe adult (RPKM 81.5) and 6 other tissues See more
Orthologs
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Genomic context

See Chn1 in Genome Data Viewer
Location:
2; 2 C3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73441004..73605723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73610660..73775367, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73448717..73613403, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), opposite strand Neighboring gene predicted gene, 53265 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene activating transcription factor 2 Neighboring gene predicted gene 10822 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-chimaerin
Names
A-chimaerin
N-chimerin
NC
alpha-chimerin
alpha1 chimaerin
alpha2 chimaerin
alpha3-chimerin
chimaerin
chimerin (chimaerin) 1
rho GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113246.2NP_001106717.2  N-chimaerin isoform 3

    See identical proteins and their annotated locations for NP_001106717.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AK019340, AK032630, AK147686, BC054770, BY638589, CA749754
    Consensus CDS
    CCDS50608.1
    UniProtKB/Swiss-Prot
    Q91V57
    Related
    ENSMUSP00000107655.4, ENSMUST00000112024.10
    Conserved Domains (3) summary
    cd10352
    Location:42128
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:266459
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:206255
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_001166603.1NP_001160075.1  N-chimaerin isoform 4

    See identical proteins and their annotated locations for NP_001160075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 3. The resulting isoform (4) lacks an internal segment, as compared to isoform 3.
    Source sequence(s)
    AB264772, AK019340, AK032630, BY638589, CA749754
    Consensus CDS
    CCDS50607.1
    UniProtKB/TrEMBL
    A7VK13
    Related
    ENSMUSP00000128847.2, ENSMUST00000166199.9
    Conserved Domains (3) summary
    cd10352
    Location:42128
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    pfam00130
    Location:206237
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:234401
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  3. NM_001166604.1NP_001160076.1  N-chimaerin isoform 5

    See identical proteins and their annotated locations for NP_001160076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple 5' exons and an in-frame exon in the coding region, as compared to variant 3. The resulting isoform (5) is shorter, has a distinct N-terminus and lacks an internal segment, as compared to isoform 3.
    Source sequence(s)
    AB264771, AK019340, AK032630, BY239371, BY638589
    UniProtKB/TrEMBL
    A7VK12
    Conserved Domains (2) summary
    pfam00130
    Location:81112
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:109276
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  4. NM_029716.3NP_083992.1  N-chimaerin isoform 2

    See identical proteins and their annotated locations for NP_083992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 5' exons but has an alternate 5' exon, as compared to variant 3. The translation initiates at the downstream AUG codon and the resulting isoform (2) has a much shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK007182, AK019340, AK032630, BY638589
    Consensus CDS
    CCDS38145.1
    UniProtKB/Swiss-Prot
    Q91V57
    UniProtKB/TrEMBL
    A7VK14
    Related
    ENSMUSP00000070301.7, ENSMUST00000070579.7
    Conserved Domains (1) summary
    cd04372
    Location:17210
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
  5. NM_175752.3NP_786928.2  N-chimaerin isoform 1

    See identical proteins and their annotated locations for NP_786928.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks multiple 5' exons and has an alternate 5' segment, as compared to variant 3. The resulting isoform (1) is shorter and has a distinct N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK019340, AK032630, AK049943, BY239371, BY638589
    Consensus CDS
    CCDS16133.1
    UniProtKB/Swiss-Prot
    Q91V57
    Related
    ENSMUSP00000099738.5, ENSMUST00000102677.11
    Conserved Domains (2) summary
    cd04372
    Location:141334
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:81133
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73441004..73605723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246554.2XP_030102414.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  2. XM_006498561.4XP_006498624.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  3. XM_006498557.3XP_006498620.2  N-chimaerin isoform X1

    Conserved Domains (3) summary
    cd10352
    Location:150236
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:348541
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:291337
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. XM_036157414.1XP_036013307.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  5. XM_036157409.1XP_036013302.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  6. XM_006498558.2XP_006498621.2  N-chimaerin isoform X2

    Conserved Domains (3) summary
    cd04372
    Location:336529
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:276325
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl15255
    Location:158198
    SH2; Src homology 2 (SH2) domain
  7. XM_030246546.1XP_030102406.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  8. XM_030246537.1XP_030102397.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  9. XM_030246534.2XP_030102394.1  N-chimaerin isoform X3

    Conserved Domains (3) summary
    cd04372
    Location:214407
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:154203
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl15255
    Location:176
    SH2; Src homology 2 (SH2) domain
  10. XM_030246543.1XP_030102403.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  11. XM_030246532.1XP_030102392.1  N-chimaerin isoform X3

    Conserved Domains (3) summary
    cd04372
    Location:214407
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:154203
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl15255
    Location:176
    SH2; Src homology 2 (SH2) domain
  12. XM_036157423.1XP_036013316.1  N-chimaerin isoform X5

    Conserved Domains (2) summary
    cd04372
    Location:41234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:132
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  13. XM_006498560.4XP_006498623.1  N-chimaerin isoform X4

    Conserved Domains (2) summary
    cd04372
    Location:93286
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:3382
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_004937502.1 RNA Sequence

  2. XR_004937500.1 RNA Sequence

  3. XR_004937503.1 RNA Sequence

  4. XR_003949984.2 RNA Sequence

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