U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ran.L RAN, member RAS oncogene family L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108716335, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ran.L
Official Full Name
RAN, member RAS oncogene family L homeolog
Primary source
Xenbase:XB-GENE-17336523
Locus tag
XELAEV_18007741mg
See related
EnsemblRapid:ENSXLAG00005011718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ran; tc4; gsp1; xran; ara24; ran-1; RanTC4
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1L
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (171390344..171396914, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (158191865..158198629, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121400934 Neighboring gene adhesion G protein-coupled receptor D1 L homeolog Neighboring gene syntaxin 2 L homeolog Neighboring gene RIMS binding protein 2 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration. Bernis C, et al. Mol Biol Cell, 2014 Apr. PMID 24478460, Free PMC Article
  2. Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis. Onuma Y, et al. Dev Genes Evol, 2000 Jun. PMID 11180838
  3. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Moore MS, et al. Nature, 1993 Oct 14. PMID 8413630
  4. Microtubule nucleation in mitosis by a RanGTP-dependent protein complex. Scrofani J, et al. Curr Biol, 2015 Jan 19. PMID 25532896
  5. Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP. Dikovskaya D, et al. J Cell Sci, 2010 Mar 1. PMID 20144988

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
    Title: Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration.
  2. Data show that importin-beta binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.
    Title: Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.
  3. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
    Title: ISWI is a RanGTP-dependent MAP required for chromosome segregation.
  4. This study identifies TPX2 as the only direct RanGTP target and NEDD1 as the only Aurora A substrate essential for the activation of the RanGTP-dependent microtubule nucleation pathway.
    Title: Microtubule nucleation in mitosis by a RanGTP-dependent protein complex.
  5. Examination of H1 histones reveals isoform-specific regulation by Cdk1 and RanGTP
    Title: Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTP.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within GTP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosomal large subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ribosomal small subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ribosomal subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within snRNA import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GTP-binding nuclear protein Ran
Names
GTPase Ran
ran GTP-binding protein
ras-like protein TC4
ras-related nuclear protein
NP_001128547.1
XP_018117934.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135075.2 → NP_001128547.1  GTP-binding nuclear protein Ran

    See identical proteins and their annotated locations for NP_001128547.1

    Status: VALIDATED

    Source sequence(s)
    BP695707, LYTH01011429, LYTH01011430
    UniProtKB/Swiss-Prot
    P52301, Q7ZYT6, Q9IBE8
    UniProtKB/TrEMBL
    A0A974E2Z5
    Related
    ENSXLAP00005034192.1, ENSXLAT00005035075.1
    Conserved Domains (2) summary
    cd00877
    Location:11 → 176
    Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
    PTZ00132
    Location:1 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    171390344..171396914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018262445.2 → XP_018117934.1  GTP-binding nuclear protein Ran isoform X1

    UniProtKB/Swiss-Prot
    P52301, Q7ZYT6, Q9IBE8
    UniProtKB/TrEMBL
    A0A974E2Z5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52301.2 GenPept UniProtKB/Swiss-Prot:P52301

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.