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Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 [ Mus musculus (house mouse) ]

Gene ID: 108760, updated on 21-Apr-2024

Summary

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Official Symbol
Galnt16provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 16provided by MGI
Primary source
MGI:MGI:1917754
See related
Ensembl:ENSMUSG00000021130 AllianceGenome:MGI:1917754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galntl1; galNAc-T16; 5730405L21Rik; mpp-GalNAc-T16
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in embryo mesenchyme; limb; and nervous system. Orthologous to human GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 9.5), cerebellum adult (RPKM 7.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C3; 12 36.79 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80565245..80650672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80518471..80603898)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46363 Neighboring gene STARR-seq mESC enhancer starr_32637 Neighboring gene STARR-seq mESC enhancer starr_32638 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene RIKEN cDNA 2310002D06 gene Neighboring gene predicted gene, 26777 Neighboring gene STARR-seq mESC enhancer starr_32641 Neighboring gene STARR-seq mESC enhancer starr_32643 Neighboring gene predicted gene, 46364 Neighboring gene predicted gene, 23817

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  2. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  3. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article
  4. O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Tian E, et al. Nat Commun, 2012 May 29. PMID 22643896, Free PMC Article
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 16
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
galNAc-T-like protein 1
polypeptide GalNAc transferase 16
polypeptide GalNAc transferase-like protein 1
pp-GaNTase-like protein 1
protein-UDP acetylgalactosaminyltransferase-like protein 1
putative polypeptide N-acetylgalactosaminyltransferase-like protein 1
NP_001074890.1
NP_001348629.1
NP_001348630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081421.2 → NP_001074890.1  polypeptide N-acetylgalactosaminyltransferase 16

    See identical proteins and their annotated locations for NP_001074890.1

    Status: VALIDATED

    Source sequence(s)
    AC125361, AC163282
    Consensus CDS
    CCDS36482.1
    UniProtKB/Swiss-Prot
    Q60GT0, Q9JJ61
    UniProtKB/TrEMBL
    Q69ZR3
    Related
    ENSMUSP00000021558.7, ENSMUST00000021558.8
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 552
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001361700.1 → NP_001348629.1  polypeptide N-acetylgalactosaminyltransferase 16

    Status: VALIDATED

    Source sequence(s)
    AC125361, AC163282
    Consensus CDS
    CCDS36482.1
    UniProtKB/Swiss-Prot
    Q60GT0, Q9JJ61
    UniProtKB/TrEMBL
    Q69ZR3
    Related
    ENSMUSP00000151829.2, ENSMUST00000219993.2
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 552
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_001361701.1 → NP_001348630.1  polypeptide N-acetylgalactosaminyltransferase 16

    Status: VALIDATED

    Source sequence(s)
    AC125361, AC163282
    Consensus CDS
    CCDS36482.1
    UniProtKB/Swiss-Prot
    Q60GT0, Q9JJ61
    UniProtKB/TrEMBL
    Q69ZR3
    Related
    ENSMUSP00000151619.2, ENSMUST00000218943.2
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 552
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80565245..80650672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134045.1: Suppressed sequence

    Description
    NM_134045.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJ61.2 GenPept UniProtKB/Swiss-Prot:Q9JJ61

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