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DINOL damage induced long noncoding RNA [ Homo sapiens (human) ]

Gene ID: 108783646, updated on 10-Oct-2023

Summary

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Official Symbol
DINOLprovided by HGNC
Official Full Name
damage induced long noncoding RNAprovided by HGNC
Primary source
HGNC:HGNC:53146
See related
Ensembl:ENSG00000285244 AllianceGenome:HGNC:53146
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DINO
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Genomic context

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Location:
6p21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36677609..36678559, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36498254..36499204, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36645386..36646336, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375038 Neighboring gene RNA, U1 small nuclear 88, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36630075-36630574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36633953-36634734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36634735-36635516 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:36644192-36645391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36646785-36647372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17119 Neighboring gene promoter of CDKN1A antisense DNA damage activated RNA Neighboring gene leucine aminopeptidase 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24440 Neighboring gene cyclin dependent kinase inhibitor 1A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17120 Neighboring gene RAB44, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36684729-36685230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36703037-36703538 Neighboring gene G protein-coupled receptor 166 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling. Sharma S, et al. mBio, 2020 Jun 16. PMID 32546626, Free PMC Article
  2. p53 partners with RNA in the DNA damage response. Huarte M. Nat Genet, 2016 Oct 27. PMID 27787509
  3. An inducible long noncoding RNA amplifies DNA damage signaling. Schmitt AM, et al. Nat Genet, 2016 Nov. PMID 27668660, Free PMC Article
  4. KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. Sharma S, et al. J Virol, 2020 Jun 1. PMID 32269126, Free PMC Article
  5. p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino. Marney CB, et al. Cell Rep, 2021 Jun 29. PMID 34192538, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.
    Title: p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.
  2. Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling.
    Title: Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM/CHK2 Signaling.
  3. KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells.
    Title: KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells.
  4. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.
    Title: p53 partners with RNA in the DNA damage response.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Other Names

  • damage induced noncoding

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_144384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    Z85996
    Related
    ENST00000643333.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36677609..36678559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36498254..36499204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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