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Mex3b mex3 RNA binding family member B [ Mus musculus (house mouse) ]

Gene ID: 108797, updated on 21-Apr-2024

Summary

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Official Symbol
Mex3bprovided by MGI
Official Full Name
mex3 RNA binding family member Bprovided by MGI
Primary source
MGI:MGI:1918252
See related
Ensembl:ENSMUSG00000057706 AllianceGenome:MGI:1918252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rkhd3; M-04814; mKIAA2009; 4931439A04Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including positive regulation of GTPase activity; positive regulation of phagocytosis; and protein localization to cell cortex. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cartilage; cranium; and reproductive system. Orthologous to human MEX3B (mex-3 RNA binding family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 55.4), CNS E14 (RPKM 46.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 47.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (82516541..82520784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (82867333..82871576)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29796 Neighboring gene STARR-seq mESC enhancer starr_19392 Neighboring gene predicted gene, 36584 Neighboring gene RIKEN cDNA 1700010L04 gene Neighboring gene STARR-seq mESC enhancer starr_19393 Neighboring gene STARR-positive B cell enhancer ABC_E10448 Neighboring gene RIKEN cDNA 4933430H16 gene Neighboring gene STARR-seq mESC enhancer starr_19395 Neighboring gene predicted gene, 45992 Neighboring gene STARR-seq mESC enhancer starr_19396 Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation. Yamazumi Y, et al. Biochem Biophys Res Commun, 2019 Nov 5. PMID 31493864
  2. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Yang Y, et al. Cell Res, 2016 Mar. PMID 26823206, Free PMC Article
  3. The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation. Yamazumi Y, et al. Cell Rep, 2016 Aug 30. PMID 27545879
  4. Use of intercross outbred mice and single nucleotide polymorphisms to map skin cancer modifier loci. Peissel B, et al. Mamm Genome, 2001 Apr. PMID 11309660
  5. The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Le Borgne M, et al. Development, 2014 May. PMID 24803656

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mex-3B facilitates the development of allergic airway inflammation by directly upregulating IL-33 expression via inhibiting miR-487b-3p mediated repression of IL-33.
    Title: The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.
  2. A study in Mex3b(-/-) mice suggest that Mex3B acts as a coreceptor of TLR3 in innate antiviral response.
    Title: The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
  3. Mex3b is involved in the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions.
    Title: The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein MEX3B
Names
RING finger and KH domain-containing protein 3
mex3 homolog B
ring finger and KH domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175366.3 → NP_780575.2  RNA-binding protein MEX3B

    Status: VALIDATED

    Source sequence(s)
    AC122736
    Consensus CDS
    CCDS52286.1
    UniProtKB/Swiss-Prot
    Q2VPR1, Q69Z36, Q6NX84, Q8K2G2
    UniProtKB/TrEMBL
    F8WJD6
    Related
    ENSMUSP00000082168.5, ENSMUST00000082237.7
    Conserved Domains (3) summary
    smart00322
    Location:167 → 232
    KH; K homology RNA-binding domain
    cd00105
    Location:74 → 134
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd16721
    Location:523 → 565
    RING-HC_MEX3B; RING finger, HC subclass, found in RNA-binding protein MEX3B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    82516541..82520784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z36.2 GenPept UniProtKB/Swiss-Prot:Q69Z36

Gene LinkOut

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