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Nusap1 nucleolar and spindle associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 108907, updated on 5-Mar-2024

Summary

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Official Symbol
Nusap1provided by MGI
Official Full Name
nucleolar and spindle associated protein 1provided by MGI
Primary source
MGI:MGI:2675669
See related
Ensembl:ENSMUSG00000027306 AllianceGenome:MGI:2675669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LNP; ANKT; SAPL; BM037; NuSAP; Q0310; 2610201A12Rik
Summary
Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Located in nucleolus. Is expressed in genitourinary system. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 34.2), liver E14.5 (RPKM 28.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 59.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119449205..119480646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119618298..119650165)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1008 Neighboring gene Opa interacting protein 5, opposite strand 1 Neighboring gene Opa interacting protein 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:119444191-119444492 Neighboring gene nuclear encoded rRNA 5S 204 Neighboring gene STARR-positive B cell enhancer ABC_E3395 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9201 Neighboring gene H3 histone, family 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction. Verbakel W, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21782797
  2. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Xie P, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21130744
  3. A role for NuSAP in linking microtubules to mitotic chromosomes. Ribbeck K, et al. Curr Biol, 2007 Feb 6. PMID 17276916
  4. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers T, et al. J Cell Biol, 2003 Sep 15. PMID 12963707, Free PMC Article
  5. NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. Vanden Bosch A, et al. J Cell Sci, 2010 Oct 1. PMID 20807801

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of mitotic spindle localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar and spindle-associated protein 1
Names
nucleolar protein ANKT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042652.2 → NP_001036117.1  nucleolar and spindle-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_001036117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AL844536
    Consensus CDS
    CCDS38206.1
    UniProtKB/Swiss-Prot
    Q9ERH4
    Related
    ENSMUSP00000028771.8, ENSMUST00000028771.8
    Conserved Domains (1) summary
    pfam16006
    Location:161 → 388
    NUSAP; Nucleolar and spindle-associated protein

  2. NM_133851.4 → NP_598612.1  nucleolar and spindle-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_598612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AL844536
    Consensus CDS
    CCDS16605.1
    UniProtKB/Swiss-Prot
    Q8C2L8, Q8C989, Q921Z0, Q9ERH4
    Related
    ENSMUSP00000068713.9, ENSMUST00000068225.15
    Conserved Domains (1) summary
    pfam16006
    Location:170 → 421
    NUSAP; Nucleolar and spindle-associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119449205..119480646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246564.2 → XP_030102424.1  nucleolar and spindle-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam16006
    Location:40 → 269
    NUSAP; Nucleolar and spindle-associated protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERH4.1 GenPept UniProtKB/Swiss-Prot:Q9ERH4

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