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Aida axin interactor, dorsalization associated [ Mus musculus (house mouse) ]

Gene ID: 108909, updated on 5-Mar-2024

Summary

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Official Symbol
Aidaprovided by MGI
Official Full Name
axin interactor, dorsalization associatedprovided by MGI
Primary source
MGI:MGI:1919737
See related
Ensembl:ENSMUSG00000042901 AllianceGenome:MGI:1919737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610208M17Rik
Summary
Enables protein domain specific binding activity. Involved in negative regulation of JNK cascade and negative regulation of protein-containing complex assembly. Acts upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Located in cytoplasm. Orthologous to human AIDA (axin interactor, dorsalization associated). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: On Build 36, NM_181732.2 was annotated on chromosome 8 on the reference assembly, chromosome 1 on the Celera assembly, and unplaced on MGSCv3. On Build 37, all placements are on chromosome 1. [04 Sep 2007]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.5), limb E14.5 (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aida in Genome Data Viewer
Location:
1; 1 H5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183078604..183105356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183297060..183324501)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. Shi M, et al. Nat Cell Biol, 2021 Mar. PMID 33664495
  2. AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Luo H, et al. Cell Metab, 2018 Apr 3. PMID 29617643
  3. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Rui Y, et al. Dev Cell, 2007 Aug. PMID 17681137
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
    Title: AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
  2. AIDA plays a central role in coordinating the abundance of the enzymes for triacylglycerol synthesis.
    Title: AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
  3. Aida blocks Axin-mediated JNK activation by disrupting Axin homodimerization. In zebrafish embryos, the dorsalization induced by axin could be repressed by aida. This activity of aida is conferred by its ability to block Axin-mediated JNK activity.
    Title: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC6869, MGC101949

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of ventral identity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of ventral identity ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
NOT involved_in negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
axin interactor, dorsalization-associated protein
Names
axin interaction partner and dorsalization antagonist

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181732.4 → NP_859421.1  axin interactor, dorsalization-associated protein

    See identical proteins and their annotated locations for NP_859421.1

    Status: VALIDATED

    Source sequence(s)
    AK081494, BC086763, BY511767
    Consensus CDS
    CCDS56663.1
    UniProtKB/Swiss-Prot
    Q3U6V0, Q3UP85, Q6NXY2, Q6PG77, Q78W09, Q8C4Q6, Q99K80
    Related
    ENSMUSP00000104795.3, ENSMUST00000109166.8
    Conserved Domains (2) summary
    pfam08910
    Location:9 → 112
    Aida_N; Aida N-terminus
    pfam14186
    Location:161 → 299
    Aida_C2; Cytoskeletal adhesion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    183078604..183105356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145626.3: Suppressed sequence

    Description
    NM_145626.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4Q6.1 GenPept UniProtKB/Swiss-Prot:Q8C4Q6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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