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Dnaaf2 dynein, axonemal assembly factor 2 [ Mus musculus (house mouse) ]

Gene ID: 109065, updated on 23-Jun-2021

Summary

Official Symbol
Dnaaf2provided by MGI
Official Full Name
dynein, axonemal assembly factor 2provided by MGI
Primary source
MGI:MGI:1923566
See related
Ensembl:ENSMUSG00000020973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ktu; kin; TU54; mknt; kintoun
Summary
This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in the human gene have been associated with primary ciliary dyskinesia. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in ovary adult (RPKM 19.8), adrenal adult (RPKM 18.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dnaaf2 in Genome Data Viewer
Location:
12; 12 C2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69235861..69245203, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69189087..69200083, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70290825..70299416, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A-like Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene mannoside acetylglucosaminyltransferase 2 Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene kelch domain containing 1 Neighboring gene kelch domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 1110034A24Rik, 2810020C19Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kintoun
Names
dynein assembly factor 2, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027269.4NP_081545.3  protein kintoun

    See identical proteins and their annotated locations for NP_081545.3

    Status: REVIEWED

    Source sequence(s)
    BC055807, BC058344
    Consensus CDS
    CCDS25948.1
    UniProtKB/Swiss-Prot
    Q8BPI1
    Related
    ENSMUSP00000021356.6, ENSMUST00000021356.6
    Conserved Domains (1) summary
    pfam08190
    Location:43352
    PIH1; pre-RNA processing PIH1/Nop17

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69235861..69245203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314934.3XP_017170423.1  protein kintoun isoform X1

    Conserved Domains (3) summary
    PHA03169
    Location:336493
    PHA03169; hypothetical protein; Provisional
    pfam08190
    Location:43206
    PIH1; pre-RNA processing PIH1/Nop17
    pfam18201
    Location:254352
    PIH1_CS; PIH1 CS-like domain
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