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Uhrf2 ubiquitin-like, containing PHD and RING finger domains 2 [ Mus musculus (house mouse) ]

Gene ID: 109113, updated on 8-Jul-2021

Summary

Official Symbol
Uhrf2provided by MGI
Official Full Name
ubiquitin-like, containing PHD and RING finger domains 2provided by MGI
Primary source
MGI:MGI:1923718
See related
Ensembl:ENSMUSG00000024817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N; Nirf; AI426270; AW214556; 2310065A22Rik; D130071B19Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.9), CNS E14 (RPKM 21.2) and 28 other tissues See more
Orthologs
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Genomic context

See Uhrf2 in Genome Data Viewer
Location:
19; 19 C1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (30007830..30071126)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (30030430..30093726)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (30105003..30168216)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26046 Neighboring gene tumor protein D52-like 3 Neighboring gene glycine decarboxylase Neighboring gene ribosomal protein L31, pseudogene 20 Neighboring gene mannose-binding lectin (protein C) 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (1)  1 citation

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in maintenance of DNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UHRF2
Names
Np95-like ring finger protein
RING-type E3 ubiquitin transferase UHRF2
nuclear protein 97
nuclear zinc finger protein Np97
ubiquitin-like PHD and RING finger domain-containing protein 2
ubiquitin-like-containing PHD and RING finger domains protein 2
NP_659122.2
XP_006526666.1
XP_036017291.1
XP_036017292.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144873.2NP_659122.2  E3 ubiquitin-protein ligase UHRF2

    See identical proteins and their annotated locations for NP_659122.2

    Status: PROVISIONAL

    Source sequence(s)
    BC060241
    Consensus CDS
    CCDS37955.1
    UniProtKB/Swiss-Prot
    Q7TMI3
    Related
    ENSMUSP00000025739.8, ENSMUST00000025739.14
    Conserved Domains (6) summary
    cd01797
    Location:176
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00213
    Location:374
    UBQ; Ubiquitin homologues
    cd00162
    Location:733776
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:347393
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:447615
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:126313
    TTD; Tandem tudor domain within UHRF1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    30007830..30071126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161398.1XP_036017291.1  E3 ubiquitin-protein ligase UHRF2 isoform X1

    Conserved Domains (7) summary
    COG5222
    Location:667767
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd15617
    Location:347393
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd16613
    Location:696741
    RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
    cd17123
    Location:174
    Ubl_UHRF2; ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:430579
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:126313
    TTD; Tandem tudor domain within UHRF1
    cl02608
    Location:370430
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  2. XM_036161399.1XP_036017292.1  E3 ubiquitin-protein ligase UHRF2 isoform X3

    Conserved Domains (6) summary
    COG5222
    Location:443543
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd15617
    Location:123169
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd16613
    Location:472517
    RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
    pfam02182
    Location:206355
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:189
    TTD; Tandem tudor domain within UHRF1
    cl02608
    Location:146206
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  3. XM_006526603.5XP_006526666.1  E3 ubiquitin-protein ligase UHRF2 isoform X2

    Conserved Domains (5) summary
    COG5222
    Location:479579
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd15617
    Location:123169
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd16613
    Location:508553
    RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
    pfam02182
    Location:223391
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:189
    TTD; Tandem tudor domain within UHRF1
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