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LOC109117331 FGF4 3' enhancer [ Homo sapiens (human) ]

Gene ID: 109117331, updated on 14-Mar-2024

Summary

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Gene symbol
LOC109117331
Gene description
FGF4 3' enhancer
Gene type
biological region
Feature type(s)
misc_feature: nucleotide_motif
regulatory: DNase_I_hypersensitive_site, enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents an enhancer located downstream of the fibroblast growth factor 4 (FGF4) coding sequence. This sequence stimulates activity of the FGF4 promoter. It includes a DNase I hypersensitive site and contains a conserved octamer element that may bind POU class homeobox proteins. [provided by RefSeq, Nov 2016]
Orthologs
mouse all
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Genomic context

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See LOC109117331 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69771454..69772169)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69788376..69789091)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69586222..69586937)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8818 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69515109-69516061 Neighboring gene FGF19 5' regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69521101-69521730 Neighboring gene MPRA-validated peak1327 silencer Neighboring gene FGF19 upstream enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69555555-69556140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69556141-69556725 Neighboring gene fibroblast growth factor 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565172-69565761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565762-69566352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69579027-69580027 Neighboring gene DNAJB6 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69588083-69589008 Neighboring gene FGF4 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596435-69596972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596973-69597508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69603612-69604157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69604158-69604702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605134-69605838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605839-69606541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69612316-69613027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69613028-69613738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69615738-69616268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69631724-69632244 Neighboring gene FGF3 5' regulatory region Neighboring gene uncharacterized LOC107984368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69640403-69641083 Neighboring gene fibroblast growth factor 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69647091-69647682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69649493-69650298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69651106-69651911 Neighboring gene MPRA-validated peak1329 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69657667-69658333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:69661705-69662302 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69679525-69680082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680083-69680640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680641-69681198 Neighboring gene fibroblast growth factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69693599-69694230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69698210-69698710 Neighboring gene Sharpr-MPRA regulatory region 8845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69705859-69706454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69720311-69720812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69724011-69724512 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69778215-69779191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69789289-69790190 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69794428-69795627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69810871-69811654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69812439-69813222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69823537-69824036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827276-69827998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827999-69828721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69832189-69833006 Neighboring gene anoctamin 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69871617-69872015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69881245-69881784 Neighboring gene long intergenic non-protein coding RNA 2753

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distal enhancer of the mouse FGF-4 gene and its human counterpart exhibit differential activity: critical role of a GT box. Boer B, et al. Mol Reprod Dev, 2005 Jul. PMID 15803454
  2. Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells. Spinella MJ, et al. Oncogene, 1998 Jul 2. PMID 9692555
  3. The FGF-4 promoter is required for transformation and is active in both embryonal and somatic cells. Lucas JM, et al. Oncol Res, 1994. PMID 7994085
  4. Regulation of FGF-4 enhancer activity by transcription factor NF-Y. Bryans M, et al. Biochem Biophys Res Commun, 1995 Jun 15. PMID 7794264
  5. Regulation of human hst expression by an enhancer element residing in the third exon. Sasaki A, et al. Jpn J Cancer Res, 1991 Nov. PMID 1836454, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052071.1 

    Range
    101..816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69771454..69772169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69788376..69789091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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