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Kif24 kinesin family member 24 [ Mus musculus (house mouse) ]

Gene ID: 109242, updated on 11-Apr-2024

Summary

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Official Symbol
Kif24provided by MGI
Official Full Name
kinesin family member 24provided by MGI
Primary source
MGI:MGI:1918345
See related
Ensembl:ENSMUSG00000028438 AllianceGenome:MGI:1918345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933425J19Rik; 9430029L23Rik
Summary
Predicted to enable identical protein binding activity and microtubule motor activity. Predicted to be involved in cilium assembly and microtubule depolymerization. Predicted to act upstream of or within cell projection organization. Predicted to be located in centriole. Predicted to be part of protein-containing complex. Orthologous to human KIF24 (kinesin family member 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.9), CNS E11.5 (RPKM 2.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Kif24 in Genome Data Viewer
Location:
4 A5; 4 21.51 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41389774..41464918, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41389964..41464919, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene predicted gene, 26084 Neighboring gene ubiquitin-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene nudix hydrolase 2 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene myogenesis regulating glycosidase (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. Ding W, et al. J Neurosci, 2019 Mar 13. PMID 30626697, Free PMC Article
  2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
  3. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024241.2 → NP_077203.2  kinesin-like protein KIF24

    See identical proteins and their annotated locations for NP_077203.2

    Status: VALIDATED

    Source sequence(s)
    AK084967, BB659870, BC067395
    Consensus CDS
    CCDS18060.2
    UniProtKB/Swiss-Prot
    A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
    Related
    ENSMUSP00000103690.3, ENSMUST00000108055.9
    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 539
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41389774..41464918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163576.1 → XP_036019469.1  kinesin-like protein KIF24 isoform X2

    Related
    ENSMUSP00000030148.6, ENSMUST00000030148.6
    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 467
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. XM_036163575.1 → XP_036019468.1  kinesin-like protein KIF24 isoform X2

    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 467
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  3. XM_006537549.5 → XP_006537612.1  kinesin-like protein KIF24 isoform X1

    See identical proteins and their annotated locations for XP_006537612.1

    UniProtKB/Swiss-Prot
    A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 539
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  4. XM_030253078.2 → XP_030108938.1  kinesin-like protein KIF24 isoform X1

    UniProtKB/Swiss-Prot
    A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 539
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  5. XM_030253077.2 → XP_030108937.1  kinesin-like protein KIF24 isoform X1

    UniProtKB/Swiss-Prot
    A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:218 → 539
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  6. XM_006537551.3 → XP_006537614.1  kinesin-like protein KIF24 isoform X4

    Conserved Domains (1) summary
    cd01367
    Location:1 → 222
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  7. XM_030253079.1 → XP_030108939.1  kinesin-like protein KIF24 isoform X5

    Conserved Domains (1) summary
    cl22853
    Location:9 → 183
    Motor_domain; Myosin and Kinesin motor domain

  8. XM_017319913.2 → XP_017175402.1  kinesin-like protein KIF24 isoform X3

    Conserved Domains (2) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cl22853
    Location:201 → 373
    Motor_domain; Myosin and Kinesin motor domain

  9. XM_036163577.1 → XP_036019470.1  kinesin-like protein KIF24 isoform X5

    Conserved Domains (1) summary
    cl22853
    Location:9 → 183
    Motor_domain; Myosin and Kinesin motor domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145101.1: Suppressed sequence

    Description
    NM_145101.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NWW5.2 GenPept UniProtKB/Swiss-Prot:Q6NWW5

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