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Cald1 caldesmon 1 [ Mus musculus (house mouse) ]

Gene ID: 109624, updated on 5-Mar-2024

Summary

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Official Symbol
Cald1provided by MGI
Official Full Name
caldesmon 1provided by MGI
Primary source
MGI:MGI:88250
See related
Ensembl:ENSMUSG00000029761 AllianceGenome:MGI:88250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
caldesmon; 4833423D12Rik; C920027I18Rik
Summary
Predicted to enable actin binding activity and myosin binding activity. Predicted to be involved in actin filament bundle assembly and angiogenesis. Predicted to act upstream of or within regulation of smooth muscle contraction. Located in actin cap and membrane. Is expressed in early conceptus; intestine smooth muscle circular layer; oocyte; and retina. Orthologous to human CALD1 (caldesmon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 210.7), placenta adult (RPKM 27.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Cald1 in Genome Data Viewer
Location:
6 B1; 6 15.07 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34575433..34752404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34598495..34775469)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52898 Neighboring gene STARR-seq mESC enhancer starr_15540 Neighboring gene predicted gene, 32942 Neighboring gene STARR-seq mESC enhancer starr_15541 Neighboring gene predicted gene 13861 Neighboring gene STARR-seq mESC enhancer starr_15542 Neighboring gene predicted gene, 38787 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene predicted gene, 46957

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle. Pütz S, et al. J Gen Physiol, 2021 Jul 5. PMID 34115104, Free PMC Article
  2. Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle. Deng M, et al. Am J Physiol Renal Physiol, 2013 Nov 15. PMID 23986516, Free PMC Article
  3. Ablation of smooth muscle caldesmon affects the relaxation kinetics of arterial muscle. Guo H, et al. Pflugers Arch, 2013 Feb. PMID 23149489, Free PMC Article
  4. Specific disruption of smooth muscle caldesmon expression in mice. Guo H, et al. Biochem Biophys Res Commun, 2005 May 20. PMID 15823561
  5. TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition. Nalluri SM, et al. Cytoskeleton (Hoboken), 2018 May. PMID 29466836

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle.
    Title: Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle.
  2. TGFbeta1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
    Title: TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
  3. Silencing of Sox4 decreased not only CaD protein synthesis but also myoblast fusion in C2C12 cells and myofibril formation in mouse embryonic muscle. Overexpression of CaD in Sox4-silenced C2C12 cells rescued the differentiation process.
    Title: Sox4-mediated caldesmon expression facilitates differentiation of skeletal myoblasts.
  4. Caldesmon-deficient mouse arterial muscles relax more slowly than wild-type tissues.
    Title: Ablation of smooth muscle caldesmon affects the relaxation kinetics of arterial muscle.
  5. distribution of the actin-binding protein caldesmon in spleen and lymph nodes of mice and rats
    Title: The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells.
  6. Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
    Title: Diversification of caldesmon-linked actin cytoskeleton in cell motility.
  7. This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 can act as an anti-motility/invasion/metastasis agent.
    Title: p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.
  8. K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells
    Title: Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of smooth muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in response to transforming growth factor beta IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cap IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caldesmon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347100.1 → NP_001334029.1  caldesmon isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102668, AC153627
    Consensus CDS
    CCDS85029.1
    UniProtKB/TrEMBL
    E9Q0M9, E9QA16
    Related
    ENSMUSP00000110678.2, ENSMUST00000115026.8
    Conserved Domains (1) summary
    pfam02029
    Location:53 → 523
    Caldesmon

  2. NM_145575.3 → NP_663550.1  caldesmon isoform 2

    See identical proteins and their annotated locations for NP_663550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC153627, AK160593, BQ769983, BY308240, CX568419
    Consensus CDS
    CCDS39456.1
    UniProtKB/TrEMBL
    D3Z6I7, Q8VCQ8
    Related
    ENSMUSP00000110673.2, ENSMUST00000115021.8
    Conserved Domains (1) summary
    pfam02029
    Location:255 → 517
    Caldesmon; Caldesmon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34575433..34752404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505348.5 → XP_006505411.1  caldesmon isoform X7

    See identical proteins and their annotated locations for XP_006505411.1

    UniProtKB/TrEMBL
    E9QA15
    Related
    ENSMUSP00000110679.2, ENSMUST00000115027.8
    Conserved Domains (1) summary
    pfam02029
    Location:363 → 759
    Caldesmon

  2. XM_006505352.4 → XP_006505415.1  caldesmon isoform X5

    UniProtKB/TrEMBL
    E9Q0M9
    Conserved Domains (1) summary
    pfam02029
    Location:53 → 523
    Caldesmon

  3. XM_036165745.1 → XP_036021638.1  caldesmon isoform X5

    UniProtKB/TrEMBL
    E9Q0M9
    Conserved Domains (1) summary
    pfam02029
    Location:53 → 523
    Caldesmon

  4. XM_030255093.1 → XP_030110953.1  caldesmon isoform X6

    UniProtKB/TrEMBL
    E9Q0M9, E9QA16
    Conserved Domains (1) summary
    pfam02029
    Location:53 → 523
    Caldesmon

  5. XM_006505345.5 → XP_006505408.3  caldesmon isoform X1

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434 → 830
    Caldesmon

  6. XM_006505346.4 → XP_006505409.3  caldesmon isoform X2

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434 → 830
    Caldesmon

  7. XM_030255090.2 → XP_030110950.2  caldesmon isoform X3

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434 → 802
    Caldesmon

  8. XM_006505351.4 → XP_006505414.3  caldesmon isoform X4

    UniProtKB/TrEMBL
    D3Z6I7
    Conserved Domains (1) summary
    pfam02029
    Location:124 → 594
    Caldesmon

RNA

  1. XR_004942901.1 RNA Sequence

  2. XR_004942902.1 RNA Sequence

  3. XR_004942906.1 RNA Sequence

  4. XR_004942907.1 RNA Sequence

  5. XR_004942903.1 RNA Sequence

  6. XR_004942899.1 RNA Sequence

  7. XR_004942898.1 RNA Sequence

  8. XR_004942900.1 RNA Sequence

  9. XR_004942904.1 RNA Sequence

  10. XR_004942905.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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