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Acy1 aminoacylase 1 [ Mus musculus (house mouse) ]

Gene ID: 109652, updated on 23-Jun-2021

Summary

Official Symbol
Acy1provided by MGI
Official Full Name
aminoacylase 1provided by MGI
Primary source
MGI:MGI:87913
See related
Ensembl:ENSMUSG00000023262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acy-; Acy-1; 1110014J22Rik
Expression
Broad expression in duodenum adult (RPKM 66.0), kidney adult (RPKM 51.7) and 19 other tissues See more
Orthologs
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Genomic context

See Acy1 in Genome Data Viewer
Location:
9 F1; 9 57.49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106310180..106315594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106432981..106438236, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (106335327..106340567, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131 Neighboring gene ribosomal protein L29 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aminoacylase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aminoacylase-1
Names
N-acyl-L-amino-acid amidohydrolase
NP_001263371.1
NP_079647.1
XP_036010451.1
XP_036010452.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276442.1NP_001263371.1  aminoacylase-1

    See identical proteins and their annotated locations for NP_001263371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003703, BX529990, CV560337
    Consensus CDS
    CCDS23477.1
    UniProtKB/Swiss-Prot
    Q99JW2
    UniProtKB/TrEMBL
    A0A0R4J050
    Related
    ENSMUST00000190851.3
    Conserved Domains (2) summary
    cd05646
    Location:9399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
    TIGR01880
    Location:1401
    Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase
  2. NM_025371.3NP_079647.1  aminoacylase-1

    See identical proteins and their annotated locations for NP_079647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003703, BX529990
    Consensus CDS
    CCDS23477.1
    UniProtKB/Swiss-Prot
    Q99JW2
    UniProtKB/TrEMBL
    A0A0R4J050
    Related
    ENSMUSP00000024031.7, ENSMUST00000024031.13
    Conserved Domains (2) summary
    cd05646
    Location:9399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
    TIGR01880
    Location:1401
    Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106310180..106315594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154558.1XP_036010451.1  aminoacylase-1 isoform X1

    Conserved Domains (1) summary
    cl14876
    Location:2312
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  2. XM_036154559.1XP_036010452.1  aminoacylase-1 isoform X1

    Conserved Domains (1) summary
    cl14876
    Location:2312
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
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