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RNA5-8SN2 RNA, 5.8S ribosomal N2 [ Homo sapiens (human) ]

Gene ID: 109864281, updated on 10-Oct-2023

Summary

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Official Symbol
RNA5-8SN2provided by HGNC
Official Full Name
RNA, 5.8S ribosomal N2provided by HGNC
Primary source
HGNC:HGNC:53521
See related
Ensembl:ENSG00000278233 AllianceGenome:HGNC:53521
Gene type
rRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNA5-8N2
Summary
45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. This gene represents a copy of the 5.8S ribosomal RNA on chromosome 21. [provided by RefSeq, Mar 2017]
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Genomic context

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Location:
21p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (8212571..8212727)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (3118648..3118804)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RNA, 45S pre-ribosomal N2 Neighboring gene microRNA 3648-1 Neighboring gene RNA, 18S ribosomal N2 Neighboring gene RNA, 28S ribosomal N2 Neighboring gene cell division cycle 27 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. Yu S, et al. Genome Biol Evol, 2016 Dec 31. PMID 27797956, Free PMC Article
  2. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. McStay B. Genes Dev, 2016 Jul 15. PMID 27474438, Free PMC Article
  3. The Epigenetic Pathways to Ribosomal DNA Silencing. Srivastava R, et al. Microbiol Mol Biol Rev, 2016 Sep. PMID 27250769, Free PMC Article
  4. Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Gibbons JG, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25583482, Free PMC Article
  5. The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure? O'Sullivan JM, et al. Biomol Concepts, 2013 Jun. PMID 25436580, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_146147.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    FP671120
    Related
    ENST00000612463.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    8212571..8212727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    3118648..3118804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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