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TLK2 tousled like kinase 2 [ Homo sapiens (human) ]

Gene ID: 11011, updated on 3-Apr-2024

Summary

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Official Symbol
TLK2provided by HGNC
Official Full Name
tousled like kinase 2provided by HGNC
Primary source
HGNC:HGNC:11842
See related
Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsHPK; MRD57; PKU-ALPHA
Summary
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TLK2 in Genome Data Viewer
Location:
17q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62470914..62615481)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63340853..63485425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60555172..60692842)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60500991-60501521 Neighboring gene methyltransferase 2A, tRNA N3-cytidine Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene mannose receptor C type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene RNA, U6 small nuclear 446, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis. Pavinato L, et al. J Med Genet, 2022 Feb. PMID 33323470, Free PMC Article
  2. TLK2 enhances aggressive phenotypes of glioblastoma cells through the activation of SRC signaling pathway. Lin M, et al. Cancer Biol Ther, 2019. PMID 30207834, Free PMC Article
  3. Molecular basis of Tousled-Like Kinase 2 activation. Mortuza GB, et al. Nat Commun, 2018 Jun 28. PMID 29955062, Free PMC Article
  4. De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder. Reijnders MRF, et al. Am J Hum Genet, 2018 Jun 7. PMID 29861108, Free PMC Article
  5. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Kim JA, et al. Nat Commun, 2016 Oct 3. PMID 27694828, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
    Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
  2. Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.
    Title: Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.
  3. Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.
    Title: Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.
  4. Study shows that TLK2 expression is increased in glioblastoma. Furthermore, TLK2 overexpression resulted in tumor growth and metastasis via SRC signaling pathway.
    Title: TLK2 enhances aggressive phenotypes of glioblastoma cells through the activation of SRC signaling pathway.
  5. haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype.
    Title: De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.
  6. Molecular basis of TLK2 activation and inhibition has been dissected.
    Title: Molecular basis of Tousled-Like Kinase 2 activation.
  7. TLK2 is amplified in aggressive luminal breast neoplasms
    Title: Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
  8. Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest.
    Title: Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest.
  9. Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage.
    Title: Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.
  10. TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation.
    Title: Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, autosomal dominant 57
MedGen: C4748003 OMIM: 618050 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tousled-like kinase 2 (TLK2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC44450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagy NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 2
NP_001271262.1
NP_001271292.1
NP_001317347.1
NP_001362198.1
NP_001362199.1
NP_001362200.1
NP_001362201.1
NP_001362202.1
NP_001398003.1
NP_006843.2
XP_011522517.2
XP_011522518.1
XP_011522520.2
XP_011522522.2
XP_011522523.1
XP_011522524.1
XP_011522525.1
XP_011522528.1
XP_011522529.1
XP_011522533.2
XP_016879533.2
XP_016879537.1
XP_016879538.1
XP_016879539.1
XP_016879540.1
XP_016879542.1
XP_016879543.1
XP_016879544.1
XP_024306320.1
XP_024306321.1
XP_047291130.1
XP_047291131.1
XP_047291132.1
XP_047291133.1
XP_047291134.1
XP_047291135.1
XP_047291136.1
XP_047291137.1
XP_047291138.1
XP_047291139.1
XP_047291141.1
XP_047291142.1
XP_047291143.1
XP_054170754.1
XP_054170755.1
XP_054170756.1
XP_054170757.1
XP_054170758.1
XP_054170759.1
XP_054170760.1
XP_054170761.1
XP_054170762.1
XP_054170763.1
XP_054170764.1
XP_054170765.1
XP_054170766.1
XP_054170767.1
XP_054170768.1
XP_054170769.1
XP_054170770.1
XP_054170771.1
XP_054170772.1
XP_054170773.1
XP_054170774.1
XP_054170775.1
XP_054170776.1
XP_054170777.1
XP_054170778.1
XP_054170779.1
XP_054170780.1
XP_054170781.1
XP_054170782.1
XP_054170783.1
XP_054170784.1
XP_054170785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284333.3 → NP_001271262.1  serine/threonine-protein kinase tousled-like 2 isoform C

    See identical proteins and their annotated locations for NP_001271262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) represents the longest transcript and encodes the longest isoform (C).
    Source sequence(s)
    AC080038, AI381985, BC044925, BX647225
    Consensus CDS
    CCDS62283.1
    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000316512.9, ENST00000326270.13
    Conserved Domains (2) summary
    cd14041
    Location:455 → 763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202 → 437
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001284363.1 → NP_001271292.1  serine/threonine-protein kinase tousled-like 2 isoform B

    See identical proteins and their annotated locations for NP_001271292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant C. The encoded protein (isoform B) is shorter than isoform C.
    Source sequence(s)
    AC008026, AC080038, AK300586, BM668399, BX647225
    Consensus CDS
    CCDS45753.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000508242.1, ENST00000683104.1
    Conserved Domains (2) summary
    COG1196
    Location:174 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401 → 709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  3. NM_001330418.3 → NP_001317347.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038, BM668399
    Consensus CDS
    CCDS82182.1
    UniProtKB/TrEMBL
    B4DUC2, J3QLK5
    Related
    ENSP00000508315.1, ENST00000683536.1
    Conserved Domains (2) summary
    COG1196
    Location:57 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:284 → 592
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  4. NM_001375269.1 → NP_001362198.1  serine/threonine-protein kinase tousled-like 2 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:220 → 517
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:447 → 755
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  5. NM_001375270.1 → NP_001362199.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  6. NM_001375271.1 → NP_001362200.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000506744.1, ENST00000682085.1
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  7. NM_001375272.1 → NP_001362201.1  serine/threonine-protein kinase tousled-like 2 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS45753.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000506988.1, ENST00000682075.1
    Conserved Domains (2) summary
    COG1196
    Location:174 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401 → 709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  8. NM_001375273.1 → NP_001362202.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS82182.1
    UniProtKB/TrEMBL
    B4DUC2, J3QLK5
    Related
    ENSP00000507584.1, ENST00000682203.1
    Conserved Domains (2) summary
    COG1196
    Location:57 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:284 → 592
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  9. NM_001411074.1 → NP_001398003.1  serine/threonine-protein kinase tousled-like 2 isoform F

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS92374.1
    UniProtKB/TrEMBL
    A0A804HK10

  10. NM_006852.6 → NP_006843.2  serine/threonine-protein kinase tousled-like 2 isoform A

    See identical proteins and their annotated locations for NP_006843.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C.
    Source sequence(s)
    AB004884, AC008026, AC080038, AF162667, AI381985, BX647225
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000275780.7, ENST00000346027.10
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    62470914..62615481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450552.2 → XP_024306320.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:462 → 770
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:209 → 444
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_024450553.2 → XP_024306321.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455 → 763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202 → 437
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_047435179.1 → XP_047291135.1  serine/threonine-protein kinase tousled-like 2 isoform X12

  4. XM_011524221.3 → XP_011522523.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423 → 731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170 → 405
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_047435182.1 → XP_047291138.1  serine/threonine-protein kinase tousled-like 2 isoform X16

  6. XM_011524216.3 → XP_011522518.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    See identical proteins and their annotated locations for XP_011522518.1

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455 → 763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202 → 437
    SMC_N; RecF/RecN/SMC N terminal domain

  7. XM_047435183.1 → XP_047291139.1  serine/threonine-protein kinase tousled-like 2 isoform X17

  8. XM_047435185.1 → XP_047291141.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9

  9. XM_047435180.1 → XP_047291136.1  serine/threonine-protein kinase tousled-like 2 isoform X13

  10. XM_017024053.3 → XP_016879542.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:174 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401 → 709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  11. XM_011524222.4 → XP_011522524.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    See identical proteins and their annotated locations for XP_011522524.1

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455 → 763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202 → 437
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_017024054.3 → XP_016879543.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9, A0A804HKF1
    Related
    ENSP00000507712.1, ENST00000684440.1

  13. XM_017024048.3 → XP_016879537.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423 → 731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170 → 405
    SMC_N; RecF/RecN/SMC N terminal domain

  14. XM_017024051.3 → XP_016879540.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000340800.7, ENST00000343388.11
    Conserved Domains (2) summary
    COG1196
    Location:174 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401 → 709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  15. XM_017024055.3 → XP_016879544.1  serine/threonine-protein kinase tousled-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A804HK10, A0A804HKF1
    Related
    ENSP00000507724.1, ENST00000684772.1

  16. XM_017024049.3 → XP_016879538.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423 → 731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170 → 405
    SMC_N; RecF/RecN/SMC N terminal domain

  17. XM_011524223.4 → XP_011522525.1  serine/threonine-protein kinase tousled-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A804HKF1
    Conserved Domains (2) summary
    smart00220
    Location:410 → 678
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:392 → 700
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  18. XM_047435174.1 → XP_047291130.1  serine/threonine-protein kinase tousled-like 2 isoform X1

  19. XM_047435176.1 → XP_047291132.1  serine/threonine-protein kinase tousled-like 2 isoform X3

  20. XM_011524215.3 → XP_011522517.2  serine/threonine-protein kinase tousled-like 2 isoform X5

  21. XM_011524218.3 → XP_011522520.2  serine/threonine-protein kinase tousled-like 2 isoform X9

  22. XM_011524220.3 → XP_011522522.2  serine/threonine-protein kinase tousled-like 2 isoform X11

  23. XM_047435181.1 → XP_047291137.1  serine/threonine-protein kinase tousled-like 2 isoform X14

  24. XM_047435177.1 → XP_047291133.1  serine/threonine-protein kinase tousled-like 2 isoform X6

  25. XM_047435178.1 → XP_047291134.1  serine/threonine-protein kinase tousled-like 2 isoform X10

  26. XM_047435175.1 → XP_047291131.1  serine/threonine-protein kinase tousled-like 2 isoform X2

  27. XM_017024044.2 → XP_016879533.2  serine/threonine-protein kinase tousled-like 2 isoform X4

  28. XM_017024050.2 → XP_016879539.1  serine/threonine-protein kinase tousled-like 2 isoform X15

    UniProtKB/TrEMBL
    A0A804HKF1
    Related
    ENSP00000507902.1, ENST00000684012.1

  29. XM_011524231.2 → XP_011522533.2  serine/threonine-protein kinase tousled-like 2 isoform X22

  30. XM_011524226.3 → XP_011522528.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    See identical proteins and their annotated locations for XP_011522528.1

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    smart00220
    Location:369 → 637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351 → 659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  31. XM_011524227.3 → XP_011522529.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    See identical proteins and their annotated locations for XP_011522529.1

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    smart00220
    Location:369 → 637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351 → 659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  32. XM_047435187.1 → XP_047291143.1  serine/threonine-protein kinase tousled-like 2 isoform X20

  33. XM_047435186.1 → XP_047291142.1  serine/threonine-protein kinase tousled-like 2 isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    63340853..63485425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314785.1 → XP_054170760.1  serine/threonine-protein kinase tousled-like 2 isoform X7

  2. XM_054314788.1 → XP_054170763.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7

  3. XM_054314792.1 → XP_054170767.1  serine/threonine-protein kinase tousled-like 2 isoform X12

  4. XM_054314796.1 → XP_054170771.1  serine/threonine-protein kinase tousled-like 2 isoform X13

  5. XM_054314800.1 → XP_054170775.1  serine/threonine-protein kinase tousled-like 2 isoform X16

  6. XM_054314786.1 → XP_054170761.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7

  7. XM_054314802.1 → XP_054170777.1  serine/threonine-protein kinase tousled-like 2 isoform X17

  8. XM_054314804.1 → XP_054170779.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9

  9. XM_054314794.1 → XP_054170769.1  serine/threonine-protein kinase tousled-like 2 isoform X13

  10. XM_054314799.1 → XP_054170774.1  serine/threonine-protein kinase tousled-like 2 isoform X16

  11. XM_054314787.1 → XP_054170762.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7

  12. XM_054314805.1 → XP_054170780.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9

  13. XM_054314795.1 → XP_054170770.1  serine/threonine-protein kinase tousled-like 2 isoform X13

  14. XM_054314801.1 → XP_054170776.1  serine/threonine-protein kinase tousled-like 2 isoform X16

  15. XM_054314809.1 → XP_054170784.1  serine/threonine-protein kinase tousled-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A804HK10

  16. XM_054314793.1 → XP_054170768.1  serine/threonine-protein kinase tousled-like 2 isoform X13

  17. XM_054314803.1 → XP_054170778.1  serine/threonine-protein kinase tousled-like 2 isoform X18

  18. XM_054314779.1 → XP_054170754.1  serine/threonine-protein kinase tousled-like 2 isoform X1

  19. XM_054314781.1 → XP_054170756.1  serine/threonine-protein kinase tousled-like 2 isoform X3

  20. XM_054314783.1 → XP_054170758.1  serine/threonine-protein kinase tousled-like 2 isoform X5

  21. XM_054314789.1 → XP_054170764.1  serine/threonine-protein kinase tousled-like 2 isoform X9

  22. XM_054314791.1 → XP_054170766.1  serine/threonine-protein kinase tousled-like 2 isoform X11

  23. XM_054314797.1 → XP_054170772.1  serine/threonine-protein kinase tousled-like 2 isoform X14

  24. XM_054314784.1 → XP_054170759.1  serine/threonine-protein kinase tousled-like 2 isoform X6

  25. XM_054314790.1 → XP_054170765.1  serine/threonine-protein kinase tousled-like 2 isoform X10

  26. XM_054314780.1 → XP_054170755.1  serine/threonine-protein kinase tousled-like 2 isoform X2

  27. XM_054314782.1 → XP_054170757.1  serine/threonine-protein kinase tousled-like 2 isoform X4

  28. XM_054314798.1 → XP_054170773.1  serine/threonine-protein kinase tousled-like 2 isoform X15

  29. XM_054314810.1 → XP_054170785.1  serine/threonine-protein kinase tousled-like 2 isoform X22

  30. XM_054314806.1 → XP_054170781.1  serine/threonine-protein kinase tousled-like 2 isoform X20

  31. XM_054314807.1 → XP_054170782.1  serine/threonine-protein kinase tousled-like 2 isoform X20

  32. XM_054314808.1 → XP_054170783.1  serine/threonine-protein kinase tousled-like 2 isoform X20

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001112707.1: Suppressed sequence

    Description
    NM_001112707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UE8.2 GenPept UniProtKB/Swiss-Prot:Q86UE8

Gene LinkOut

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