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Mpi mannose phosphate isomerase [ Mus musculus (house mouse) ]

Gene ID: 110119, updated on 5-Jan-2022

Summary

Official Symbol
Mpiprovided by MGI
Official Full Name
mannose phosphate isomeraseprovided by MGI
Primary source
MGI:MGI:97075
See related
Ensembl:ENSMUSG00000032306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpi1; Mpi-1; AI315153; 1110002E17Rik
Summary
Enables mannose-6-phosphate isomerase activity. Acts upstream of or within GDP-mannose biosynthetic process and mannose to fructose-6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis adult (RPKM 49.7), large intestine adult (RPKM 32.3) and 26 other tissues See more
Orthologs
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Genomic context

See Mpi in Genome Data Viewer
Location:
9 B; 9 31.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57448744..57460095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57544260..57552812, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (57392075..57400559, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene family with sequence similarity 219, member B Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51-like kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Mpi gene: The Mpi gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 419 organisms have orthologs with human gene Mpi
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables mannose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannose-6-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mannose-6-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mannose-6-phosphate isomerase
Names
PMI
mannose phosphate isomerase 1
phosphohexomutase
phosphomannose isomerase
NP_080113.1
XP_006510834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025837.2NP_080113.1  mannose-6-phosphate isomerase

    See identical proteins and their annotated locations for NP_080113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK132777
    Consensus CDS
    CCDS40650.1
    UniProtKB/Swiss-Prot
    Q924M7
    UniProtKB/TrEMBL
    Q3V100
    Related
    ENSMUSP00000034856.9, ENSMUST00000034856.15
    Conserved Domains (2) summary
    COG1482
    Location:9403
    ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
    pfam01238
    Location:6381
    PMI_typeI; Phosphomannose isomerase type I

RNA

  1. NR_151692.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC164548

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57448744..57460095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510771.4XP_006510834.1  mannose-6-phosphate isomerase isoform X1

    Conserved Domains (1) summary
    cl21464
    Location:3192
    cupin_like; Conserved domain found in cupin and related proteins

RNA

  1. XR_001778789.3 RNA Sequence

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