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H2-Q6 histocompatibility 2, Q region locus 6 [ Mus musculus (house mouse) ]

Gene ID: 110557, updated on 16-Oct-2021

Summary

Official Symbol
H2-Q6provided by MGI
Official Full Name
histocompatibility 2, Q region locus 6provided by MGI
Primary source
MGI:MGI:95935
See related
Ensembl:ENSMUSG00000073409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qa6; Qa-6; H-2Q6; H2-K1; 0610037M15Rik
Expression
Broad expression in spleen adult (RPKM 225.2), mammary gland adult (RPKM 127.6) and 15 other tissues See more
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Genomic context

See H2-Q6 in Genome Data Viewer
Location:
17 B1; 17 18.66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35643826..35649031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35424850..35430055)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35561822..35565306)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene archain 1 pseudogene Neighboring gene predicted gene, 32252 Neighboring gene histocompatibility 2, Q region locus 7 Neighboring gene archain 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histocompatibility 2, Q region locus 6
Names
MHC class II antigen K
put. Q8 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368741.1NP_001355670.1  histocompatibility 2, Q region locus 6 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS37598.1
    Conserved Domains (2) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. NM_001368742.1NP_001355671.1  histocompatibility 2, Q region locus 6 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 2. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    CR974466
    Conserved Domains (2) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. NM_207648.2NP_997531.1  histocompatibility 2, Q region locus 6 isoform a precursor

    See identical proteins and their annotated locations for NP_997531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS37598.1
    UniProtKB/TrEMBL
    P79568
    Related
    ENSMUSP00000134550.2, ENSMUST00000174699.8
    Conserved Domains (2) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35643826..35649031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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