H2-Q9 histocompatibility 2, Q region locus 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Q9provided by MGI
Official Full Name: histocompatibility 2, Q region locus 9provided by MGI
Primary source: MGI:MGI:95938
See related: AllianceGenome:MGI:95938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ped; Qa9; Qa-2; Qa-9; H-2Q9
Summary: Enables peptide antigen binding activity. Acts upstream of or within several processes, including defense response to other organism; positive regulation of T cell mediated cytotoxicity; and positive regulation of interferon-gamma production. Located in external side of plasma membrane. Part of MHC class Ib protein complex. Is expressed in early conceptus; inner cell mass; and spleen. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 17 B1; 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35752074..35756659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17 Unlocalized Scaffold (129X1/SvJ)	NT_039662.3 (1714853..1719494)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nonpolymorphic, nonclassical H2-Q9 serves as a restriction element for antitumor cytotoxic T lymphocytes and protects syngeneic hosts from melanoma outgrowth.
Title: A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.
During primary and secondary rejection of tumors, Q9 is recognized by cross-reactive antitumor cytotoxic T cells, has overlapping peptide-binding motifs, and is assembled via the transporter associated with the antigen processing pathway.
Title: The role of structurally conserved class I MHC in tumor rejection: contribution of the Q8 locus.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H2-Q7 (e-PCR), detects polymorphism
- UniSTS:525236

H2-Q7 (e-PCR), detects polymorphism
- UniSTS:143311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class Ib protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: H-2 class I histocompatibility antigen, Q9 alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201460.1 → NP_001188389.1 H-2 class I histocompatibility antigen, Q9 alpha chain isoform 1 precursor

See identical proteins and their annotated locations for NP_001188389.1

Status: VALIDATED

Source sequence(s)

AY989883, BP762043, BY197645, CN717653

UniProtKB/TrEMBL

E9QJR9, Q52PG7

Conserved Domains (2) summary

cd07698
Location:204 → 295

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001404051.1 → NP_001390980.1 H-2 class I histocompatibility antigen, Q9 alpha chain isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CU467494
NM_001404052.1 → NP_001390981.1 H-2 class I histocompatibility antigen, Q9 alpha chain isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CU467494