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Prps2 phosphoribosyl pyrophosphate synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 110639, updated on 11-Apr-2024

Summary

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Official Symbol
Prps2provided by MGI
Official Full Name
phosphoribosyl pyrophosphate synthetase 2provided by MGI
Primary source
MGI:MGI:97776
See related
Ensembl:ENSMUSG00000025742 AllianceGenome:MGI:97776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prps-2; 2610101M19Rik
Summary
Predicted to enable several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and AMP biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in alimentary system; central nervous system; and retina. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.7), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F5; X 78.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166129316..166165887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167346320..167382872, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chrX:163766615-163766916 Neighboring gene STARR-seq mESC enhancer starr_48272 Neighboring gene STARR-seq mESC enhancer starr_48273 Neighboring gene STARR-seq mESC enhancer starr_48274 Neighboring gene toll-like receptor 8 Neighboring gene toll-like receptor 7 Neighboring gene predicted gene 15239 Neighboring gene predicted gene, 26368 Neighboring gene predicted gene 6744 Neighboring gene FERM and PDZ domain containing 4 Neighboring gene BTB (POZ) domain containing 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis. Lei B, et al. Asian J Androl, 2020 Sep-Oct. PMID 31736475, Free PMC Article
  2. PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells. Lei B, et al. J Urol, 2015 Nov. PMID 26004865
  3. Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Zhang F, et al. Nat Commun, 2015 Jul 15. PMID 26175007, Free PMC Article
  4. Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Taira M, et al. Biochim Biophys Acta, 1989 Mar 1. PMID 2537655
  5. Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome. Lee K, et al. Mamm Genome, 1994 Oct. PMID 7849396

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
    Title: Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
  2. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway.
    Title: PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
  3. Study demonstrates with a Prps2 knockout mouse that the nexus between protein and nucleotide biosynthesis controlled by PRPS2 is crucial for Myc-driven tumorigenesis.
    Title: Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28388

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
  
enables AMP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose phosphate diphosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribose phosphate diphosphokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ribose phosphate diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose-phosphate shunt IC
Inferred by Curator
more info
 PubMed 
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribose phosphate diphosphokinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribose-phosphate pyrophosphokinase 2
Names
PRS-II
phosphoribosyl pyrophosphate synthase II
phosphoribosyl pyrophosphate synthetase II
NP_001300687.1
NP_080938.1
XP_017173840.1
XP_017173841.1
XP_036017671.1
XP_036017672.1
XP_036017673.1
XP_036017674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313758.1 → NP_001300687.1  ribose-phosphate pyrophosphokinase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029690, AL731735, AV467400, BY127801, CF733337
    UniProtKB/TrEMBL
    Q3TI27, Q3UPD5
    Conserved Domains (3) summary
    COG0462
    Location:1 → 316
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:4 → 123
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    cl00309
    Location:164 → 316
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

  2. NM_026662.5 → NP_080938.1  ribose-phosphate pyrophosphokinase 2 isoform 2

    See identical proteins and their annotated locations for NP_080938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK029690, AL731735, AV467400, BY127801
    Consensus CDS
    CCDS30532.1
    UniProtKB/Swiss-Prot
    Q9CS42, Q9CZA9
    UniProtKB/TrEMBL
    Q3TI27, Q3UPD5
    Related
    ENSMUSP00000026839.5, ENSMUST00000026839.5
    Conserved Domains (3) summary
    COG0462
    Location:1 → 313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:4 → 120
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    cl00309
    Location:161 → 313
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    166129316..166165887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161779.1 → XP_036017672.1  ribose-phosphate pyrophosphokinase 2 isoform X2

    Conserved Domains (1) summary
    COG0462
    Location:189 → 461
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  2. XM_036161778.1 → XP_036017671.1  ribose-phosphate pyrophosphokinase 2 isoform X1

    Conserved Domains (1) summary
    COG0462
    Location:189 → 464
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  3. XM_036161781.1 → XP_036017674.1  ribose-phosphate pyrophosphokinase 2 isoform X4

    Conserved Domains (1) summary
    pfam13793
    Location:189 → 251
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

  4. XM_036161780.1 → XP_036017673.1  ribose-phosphate pyrophosphokinase 2 isoform X3

    Conserved Domains (1) summary
    pfam13793
    Location:189 → 250
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

  5. XM_017318352.3 → XP_017173841.1  ribose-phosphate pyrophosphokinase 2 isoform X6

    Conserved Domains (1) summary
    pfam13793
    Location:85 → 184
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

  6. XM_017318351.3 → XP_017173840.1  ribose-phosphate pyrophosphokinase 2 isoform X5

    Conserved Domains (1) summary
    pfam13793
    Location:85 → 183
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CS42.4 GenPept UniProtKB/Swiss-Prot:Q9CS42

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