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Aldh7a1 aldehyde dehydrogenase family 7, member A1 [ Mus musculus (house mouse) ]

Gene ID: 110695, updated on 5-Jan-2022

Summary

Official Symbol
Aldh7a1provided by MGI
Official Full Name
aldehyde dehydrogenase family 7, member A1provided by MGI
Primary source
MGI:MGI:108186
See related
Ensembl:ENSMUSG00000053644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atq1; D18Wsu181e
Summary
Predicted to enable identical protein binding activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Used to study pyridoxine-dependent epilepsy. Human ortholog(s) of this gene implicated in pyridoxine-dependent epilepsy. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in placenta adult (RPKM 56.9), liver adult (RPKM 51.3) and 23 other tissues See more
Orthologs
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Genomic context

See Aldh7a1 in Genome Data Viewer
Location:
18 D3; 18 30.55 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56657794..56706112, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56524722..56572991, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (56685390..56732593, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102637792 Neighboring gene GRAM domain containing 3 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene microRNA 1258 Neighboring gene phosphorylated adaptor for RNA export Neighboring gene testis expressed 43 Neighboring gene predicted gene, 50288

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-aminoadipic semialdehyde dehydrogenase
Names
P6c dehydrogenase
aldehyde dehydrogenase 7 family, member A1
alpha-AASA dehydrogenase
antiquitin-1
betaine aldehyde dehydrogenase
delta1-piperideine-6-carboxylate dehydrogenase
delta1-piperideine-6-carboxylate dehydrogenease
NP_001120810.1
NP_613066.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127338.1NP_001120810.1  alpha-aminoadipic semialdehyde dehydrogenase isoform b

    See identical proteins and their annotated locations for NP_001120810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK004991, CJ156580
    Consensus CDS
    CCDS50291.1
    UniProtKB/Swiss-Prot
    Q9DBF1
    Related
    ENSMUSP00000133372.2, ENSMUST00000174518.8
    Conserved Domains (1) summary
    cd07130
    Location:25499
    ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
  2. NM_138600.4NP_613066.2  alpha-aminoadipic semialdehyde dehydrogenase isoform a

    See identical proteins and their annotated locations for NP_613066.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK004991, AK169195, BY017676
    Consensus CDS
    CCDS29258.2
    UniProtKB/Swiss-Prot
    Q9DBF1
    Related
    ENSMUSP00000065089.7, ENSMUST00000066208.13
    Conserved Domains (1) summary
    cd07130
    Location:53527
    ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56657794..56706112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952489.2 RNA Sequence

  2. XR_385969.5 RNA Sequence

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