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Adam33 a disintegrin and metallopeptidase domain 33 [ Mus musculus (house mouse) ]

Gene ID: 110751, updated on 25-Apr-2024

Summary

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Official Symbol
Adam33provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 33provided by MGI
Primary source
MGI:MGI:1341813
See related
Ensembl:ENSMUSG00000027318 AllianceGenome:MGI:1341813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adaml
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is widely expressed, most highly in the adult brain, heart, kidney, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Biased expression in bladder adult (RPKM 51.9), limb E14.5 (RPKM 19.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 63.26 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130892739..130905734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131050819..131063814, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39937 Neighboring gene microRNA 6973b Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4 Neighboring gene sialic acid binding Ig-like lectin 1, sialoadhesin Neighboring gene STARR-seq mESC enhancer starr_05699 Neighboring gene predicted gene, 30378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Chen C, et al. Mol Cell Biol, 2006 Sep. PMID 16943435, Free PMC Article
  2. Mouse ADAM33: two splice variants differ in protein maturation and localization. Umland SP, et al. Am J Respir Cell Mol Biol, 2004 Apr. PMID 12972401
  3. Identification and preliminary characterization of mouse Adam33. Gunn TM, et al. BMC Genet, 2002. PMID 11897009, Free PMC Article
  4. Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. Haitchi HM, et al. J Allergy Clin Immunol, 2009 Sep. PMID 19665773
  5. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Van Eerdewegh P, et al. Nature, 2002 Jul 25. PMID 12110844

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adam33/Adam33 shows 2 significant increments in expression during lung morphogenesis, suggesting important developmental regulation.
    Title: Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
  2. ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness.
    Title: ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
  3. The mouse and human predicted proteins consisted of 797 and 813 amino acids, respectively, and they shared 70% homology of the entire amino acid sequence.
    Title: Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity.
  4. Identification and preliminary characterization of mouse Adam33.
    Title: Identification and preliminary characterization of mouse Adam33.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokine production NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 33
Names
a disintegrin and metalloprotease domain 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163529.2 → NP_001157001.1  disintegrin and metalloproteinase domain-containing protein 33 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AL833771, AW048228, BC138139
    Consensus CDS
    CCDS50716.1
    UniProtKB/TrEMBL
    A2AP51, Q6TYZ0
    Related
    ENSMUSP00000052486.4, ENSMUST00000052104.10
    Conserved Domains (5) summary
    smart00050
    Location:427 → 501
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:503 → 644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211 → 408
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:57 → 165
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_033615.3 → NP_291093.2  disintegrin and metalloproteinase domain-containing protein 33 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_291093.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL833771, AW048228, BC138139
    Consensus CDS
    CCDS16753.1
    UniProtKB/Swiss-Prot
    Q8R5G5, Q923W9
    UniProtKB/TrEMBL
    Q6TYY9
    Related
    ENSMUSP00000105861.3, ENSMUST00000110232.9
    Conserved Domains (5) summary
    smart00050
    Location:427 → 501
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:503 → 645
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211 → 408
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:57 → 165
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. NR_136922.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL833771, AW048228, BC138139

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130892739..130905734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498576.3 → XP_006498639.2  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

    UniProtKB/TrEMBL
    Q6TYY9
    Conserved Domains (4) summary
    smart00050
    Location:414 → 488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:490 → 632
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:39 → 168
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_011239248.2 → XP_011237550.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    See identical proteins and their annotated locations for XP_011237550.1

    UniProtKB/TrEMBL
    Q6TYY9
    Conserved Domains (3) summary
    smart00050
    Location:291 → 365
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:367 → 509
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:75 → 272
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

  3. XM_011239250.4 → XP_011237552.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    See identical proteins and their annotated locations for XP_011237552.1

    UniProtKB/TrEMBL
    Q6TYY9
    Conserved Domains (3) summary
    smart00050
    Location:291 → 365
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:367 → 509
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:75 → 272
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

  4. XM_011239251.1 → XP_011237553.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    See identical proteins and their annotated locations for XP_011237553.1

    UniProtKB/TrEMBL
    Q6TYY9
    Related
    ENSMUSP00000122608.2, ENSMUST00000135149.8
    Conserved Domains (3) summary
    smart00050
    Location:291 → 365
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:367 → 509
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:75 → 272
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

  5. XM_011239249.1 → XP_011237551.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    See identical proteins and their annotated locations for XP_011237551.1

    UniProtKB/TrEMBL
    Q6TYY9
    Conserved Domains (3) summary
    smart00050
    Location:291 → 365
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:367 → 509
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:75 → 272
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

  6. XM_011239252.4 → XP_011237554.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

    UniProtKB/TrEMBL
    Q6TYZ0
    Conserved Domains (4) summary
    smart00050
    Location:427 → 501
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:503 → 637
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:39 → 168
    Pep_M12B_propep; Reprolysin family propeptide

  7. XM_011239255.3 → XP_011237557.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

    See identical proteins and their annotated locations for XP_011237557.1

    Conserved Domains (2) summary
    cd04269
    Location:211 → 361
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:39 → 168
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_001780409.2 RNA Sequence

  2. XR_004937534.1 RNA Sequence

  3. XR_001780411.3 RNA Sequence

  4. XR_004937535.1 RNA Sequence

    Related
    ENSMUST00000132436.8

  5. XR_866209.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923W9.3 GenPept UniProtKB/Swiss-Prot:Q923W9

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